Objective: For the appropriate treatment of patients with chest-pain, measuring true CK-MB values is important for the early identification of myocardial infarction. The objective of our study was to compare the diagnostic value of the two different methods in patients with acute myocardial infarction, healty controls with high CK levels and healty controls with normal total CK level plus high CK-MB level.

Materials and Methods: 16 patients diagnosed AMI who referred to the emergency clinic, 30 healty controls with high CK levels and 30 with normal total CK level and high CK-MB level were enrolled in this study. Total CK and CK-MB activities were measured by photometric and CK-MB mass levels were determined with chemiluminometric methods.

Results: When the three groups CK-MB activity and mass values were evaluated with lineer regression/ correlation analyses; there were no significant correlations between CK-MB mass and CK-MB activity values in both control groups (r = -0.013, p = 0.945 and r = 0.042, p = 0.825) however in patients with AMI there was sigificant correlation (r=0.909, p = 0.000).

Conclusion: In healthy groups there may be positive interferences when immunoinhibition technique is used. However, in acute myocardial infarction group, where the increases are really cardiac in origine, these interferences are less prominent.