Journal of Turkish Clinical Biochemistry

The official publication of Turkish Society of Clinical Biochemistry

Diamond OA
No APCs
First Decision
30 Days
Indexed In
TR Dizin
Original Research
April 01, 2014
JTCB. 2014 Apr 1; 12 (1) : 015-020

Relationship Between Obesity Indices and C-Peptide in Healthy Adult Men

1 Sütçü İmam Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya AD, Kahramanmaraş, Türkiye
2 Necip Fazıl Şehir Hastanesi, Biyokimya Laboratuvarı, Kahramanmaraş, Türkiye
3 Dr. Ersin Arslan Devlet Hastanesi, Biyokimya Laboratuvarı, Gaziantep, Türkiye

Abstract

Objective: The aim of the present study is to investigate the relation between new obesity indices waist circumference/height (WtHR), visceral adiposity index (VAI) and body adiposity index (BAI) and homeostasis model assessment of insülin resistance (HOMA-IR) index and pancreatic beta cell function in healthy adult men.

Materials and Methods: Non-smoker and non-drinker 51 healthy adult men whose HOMA-IR index were under the 2,5 included to this study. Fasting serum glucose, triglyceride, HDL, insulin and Cpeptide levels were measured and body mass index (BMI), WtHR, BAI and VAI were calculated. Insulin resistance was considered by HOMA-IR index; beta cell function and insulin secretion were considered by serum C-peptide level. Pearson's correlation test was performed to correlation analysis.

Results: WtHR showed positive correlations with serum glucose, insülin and C-peptide levels (r values were; 0,411; 0,341 and 0,451 respectively). In addition BMI showed positive correlations with serum glucose, insülin and C-peptide levels too (r values were; 0,424; 0,396 and 0,473 respectively). VAI showed positive correlations with serum glucose and C-peptide levels (r values were; 0,725 and 0,354 respectively). BAI was not correlated with any biochemical parameters excepted HOMA-IR index. There were positive correlations between the HOMA-IR index and all of the obesity indices (r values were 0,434; 0,455; 0,526 and 0,572 respectively for BAI, VAI, WHtR and BMI).

Conclusion: WtHR and BMI showed the strongest relationships with beta cell activity and insülin resistance. WHtR is the most reminder of BMI in this aspect. Although some metabolic parameters were used in calculation of VAI, it showed similar results to other indices. Whereas BAI was related to insülin resistance, it wasn't related to insülin secretion.

Citation

Çelik, Ahmet, Gürkan Çıkım, Edibe Sarıçiçek, Elif Şahin, and Metin Kılınç. 2014. “Relationship Between Obesity Indices and C-Peptide in Healthy Adult Men”. Journal of Turkish Clinical Biochemistry 12 (1):015-020. https://turkclinbiochem.org/index.php/pub/article/view/196.

Publish with JTCB

Diamond Open Access

Fully Diamond OA with no APCs and no submission fees. Your research is freely available to readers worldwide from the day it publishes.

30-Day First Decision

Double-blind peer review from an active editorial team returns a first decision in about 30 days, keeping your manuscript moving.

Global Platform

Backed by the Turkish Society of Clinical Biochemistry, JTCB welcomes submissions from researchers worldwide and reaches an international laboratory audience.

Focused Laboratory Scope

Method validation, analyzer comparisons, reference intervals, quality indicators, preanalytical studies, and instructive clinical case reports.

Credible and Discoverable

All manuscripts publish in English and follow ICMJE and COPE guidelines, with Crossref DOIs and TR Dizin indexing ensuring global discoverability.