Journal of Turkish Clinical Biochemistry

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December 01, 2014
JTCB. 2014 Dec 1; 12 (3) : 131-136
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Determination of Vitamin B12 and Folic Acid Reference Intervals at Kartal District

Yalçın Önder1, Sehavet Tezcan2, Özlem Hürmeydan Kadılar3, Lale Köroğlu Dağdelen4, Özlem Çakır Madenci4, Nihal Yücel4, Asuman Orçun4
1 Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Halk Sağlığı, TOKAT, Türkiye
2 M.Enver Şenerdem Torbalı Devlet Hastanesi, Tıbbi Biyokimya, İZMİR, Türkiye
3 Sakarya Üniversitesi Eğitim ve Araştırma Hastanesi, Tıbbi Biyokimya, SAKARYA, Türkiye
4 Dr. Lütfi Kırdar Eğitim ve Araştırma Hastanesi, Tıbbi Biyokimya, İSTANBUL, Türkiye

Abstract

Purpose: The purpose of this study is to determine serum B12 and folic acid reference values that can be used in our hospital district population.

Materials and Methods: 300 healthy individuals were chosen according to CLSI Approved Guideline C28-A. Serum levels of vitamin B12and folic acid were analyzed by ADVIA Centaur XP immunoassay System. The reference intervals are calculated using Analyse-it for Microsoft Excel Version 2.20 program.

Results: The mean±SD of vitamin B12level was 301,57±114,6 pg/ml (297,19±111,6 pg/ml male, 304,97±117,2 pg/ml in female), the mean±SD of folate level was 8,70±3,90 ng/ml (8,54±4,04 ng/ml in male, 8,81±3,81 ng/ml in female). Vitamin B12reference intervals were found as 155-639 pg/ml. Folate reference intervals were found as 2,87-19,49 ng/ml.

Conclusion: The reference values that we found in our study were different from the values recommended by the manufacturer company. We think that these values reflect our hospital population more truly than manufacturer's and should be used as reference intervals.

Keywords

Vitamin B12; Folic acid; Reference interval

Citation

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Önder, Yalçın, Sehavet Tezcan, Özlem Hürmeydan Kadılar, Lale Köroğlu Dağdelen, Özlem Çakır Madenci, Nihal Yücel, and Asuman Orçun. 2014. “Determination of Vitamin B12 and Folic Acid Reference Intervals at Kartal District”. Journal of Turkish Clinical Biochemistry 12 (3):131-36. https://turkclinbiochem.org/index.php/pub/article/view/211.
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