Introduction: Diabetic nephropathy is the most common cause of end stage renal disease. Early diagnosis of diabetic nephropathy is essential for prevention progression to end stage renal disease.

Aim: The aim of this study was to evaluate the association of specific proteins such as transferrin, ceruloplasmin, alpha-2-macroglobulin, alpha-1-antitrypsin, IgG, IgM, beta-2-microglobulin with glycemic control and to investigate the usefulness of using these markers in early diagnosis of nephropathy in subjects nephropathy developed or not in type II diabetic patients.

Materials and Methods: 34 Type 2 Diabetes Mellitus (DM) patients with diabetic nephropathy and 58 Type2 DM patients without complications were included in this study.

Results: Serum TRF levels of macroalbuminuria group were significantly lower (p<0.05), however serum α1-antitrypsin (A1AT), serum and urine B2MG, microalbumin levels were higher than normoalbuminuria group (For all p<0.001). Diabetic nephropathy group had a significant inverse correlation between serum B2MG and fructosamine (r=-0.739, p=0.023).

Conclusion: In conclusion, it was found that there was a decline in TRF level and elevations in urinary and serum B2MG levels in Type 2 diabetic patients with macroalbuminuria proportional to degree of nephropathy. It was observed that B2MG levels are related with glicemic control. Moreover, serum A1AT level is also an important predictor in demonstration of the tubular injury and monitorization of nephropathy independently from glycemic control.