Introduction: The disease caused by SARS-CoV-2, which the World Health Organization has considered as a pandemic, was named COVID-19 and has since spread worldwide. The COVID-19 pandemic has drastically changed the way we live and work. During events like COVID-19, it is very important to manage resources and supplies correctly in medical laboratories. This article aims to explore the changes in laboratory test demands during the COVID-19 pandemic.

Materials and Methods: The statistics of medical biochemistry laboratory test consumption between the pre-pandemic period (April 2019 - 2020) and the pandemic period (April 2020 - 2021) were evaluated using the hospital information system. Changes in the number of biochemistry tests were given as percentages.

Results: Total specimens received for testing in April 2020-2021 showed a decline of 63.22% compared to April 2019-2020. An increase in test demands of prognostic biomarkers for COVID-19; including fibrinogen, D-dimer, procalcitonin, CRP, troponin I, prealbumin, blood gas analysis was noted in contrast to the overall decline.

Conclusions: It was concluded that it is very important for clinical laboratory managers to be prepared and careful, as significant changes were detected in general routine biochemical test consumptions and COVID-19 prognostic biomarker test requests during the pandemic compared to the pre-pandemic period.