Journal of Turkish Clinical Biochemistry

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April 01, 2022
JTCB. 2022 Apr 1; 20 (1) : 054-062
DOI 10.56615/tkbd.2022.07
84 92
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Change of Lipid Profile and Oxidative Stress Markers with Treatment in Hypogonad Patients

Kenan Güçlü1, Fahri Bayram2, Gülden Başkol3, Osman Başpınar4, Aydoğan Aydoğdu5
1 Ahi Evran University Faculty of Medicine, Department of Biochemistry, Kırşehir, Türkiye
2 Erciyes University Faculty of Medicine, Department of Endocrinology and Metabolism, Kayseri, Türkiye
3 Erciyes University Faculty of Medicine, Department of Biochemistry, Kayseri, Türkiye
4 Kayseri Training and Research Hospital, Department of Internal Medicine, Kayseri, Türkiye
5 Gülhane Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Türkiye

Abstract

Aim: To investigate the presence of oxidative stress and dyslipidemia, which increase cardiovascular risk, and the effect of gonadotropin replacement therapy on these parameters in patients with Idiopathic Hypogonadotropic Hypogonadism (IHH).

Material and Methods: This was a phase IV, non-randomized, case-controlled study. Male patients diagnosed with IHH (n=30), and a control group of healthy participants with similar age and body mass index (BMI) (n=20) were included. Oxidative stress markers, lipids and apolipoprotein levels were measured before and after gonadotropin treatment and compared with healthy controls.

Results: After treatment, a dramatic decrease was observed in high-density lipoprotein (HDL), lowdensity lipoprotein (LDL), advanced oxidation protein products (AOPP), malondialdehyde (MDA) and nitric oxide (NO) levels, while a significant increase in thiol level was detected (p<0.05).

Conclusion: The data obtained indicated the presence of dyslipidemia and an increase in oxidative stress in hypogonadism cases, and showed that gonadotropin treatment reduced the oxidative stress of patients and positively affected their lipid profile.

Keywords

Hypogonadism oxidative stress gonadotropin

Citation

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Güçlü, Kenan, Fahri Bayram, Gülden Başkol, Osman Başpınar, and Aydoğan Aydoğdu. 2022. “Change of Lipid Profile and Oxidative Stress Markers With Treatment in Hypogonad Patients”. Journal of Turkish Clinical Biochemistry 20 (1):054-062. https://doi.org/10.56615/tkbd.2022.07.
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