Objectives: Despite various studies on the effect of thyroid status on insulin sensitivity in recent years, there are conflicting data. Thyroid dysfunction leads to changes in glucose and lipid metabolism, which is an important risk factor for cardiovascular diseases. For this reason, the patient must be carefully monitored and treated to prevent future diseases. Here we investigated the association between hypothyroidism and insulin resistance (IR) indicesMaterials and

Methods: 41 hypothyroidism patients and 249 healthy age and sex matched controls in the age group of 18 to 65 years were taken for the study. Care was taken to ensure that all participants were non-diabetic. Glucose (Glu), Trigliserid (TG), insulin (I), Total cholesterol (CHOL), HDL Cholesterol (HDL), as well as Thyroid Stimulating Hormone (TSH), free thyroxin (fT4) and free triiodotronin (fT3) values were examined in the patient and control groups. Afterwards, IR parameters like HOMA-IR, TyG index, TG/HDL, ISI, QUICKI were calculated and investigated whether there was a significant difference between the groups.

Results: The groups were statistically equal in terms of age and gender. (P=0,29, P= 0,32). When we examined the insulin resistance indexes, we observed that there were significant differences in the TyG index and TG/HDL ratio (P=0.03, P=0.04). Apart from this, we did not find any significant difference in HOMA-IR, QUICKI and ISI parameters and their p values were 0.27, 0.27 and 0.1 respectively. The AUC values after the receiver operating characteristic (ROC) analysis for TyG index and TG/HDL were 0.602 and 0.598, respectively, and p values were 0.045 and 0.04, respectively.

Conclusion: This study highlights the effectiveness of the TyG index and TG/HDL ratio as a diagnostic tool for IR in patients with hypothyroidism and establishes it as an effective alternative to HOMA-IR, ISI and QUICKI.