Aim: Method evaluation studies should be carried out for every new method planned to be used in laboratories. The aim of this study is to determine the analytical performance of the immunoassay method used for determining of plasma 25-hydroxy vitamin D levels and also to...

Objective: However, the analytical and standardization problems have continued, vitamin D status is usually assessed by measuring the plasma concentration of 25-hydroxyvitamin D [25(OH)D]. The aim of this study was to compared vitamin D levels of 50 healthy volunteers...

Aim: Six Sigma methodology used in clinical laboratories is a quality management tool based on statistical calculations, focusing on process variables and providing information about process performance. In this study, we aimed to evaluate the analytical process performances...

Aim: Six Sigma is a quality management tool that helps continuously monitor and improve the performance of the tests in the clinical laboratory. The quality goal index (QGI) ratio represents the state of meeting the respective quality targets of both bias and precision. The...

Aim: /b> In this study, we evaluated the analytical performance and diagnostic adequacy of the activity and mass methods used for the measurement of CK-MB, a laboratory marker for the diagnosis of acute myocardial infarction (AMI). In addition, the differences between CK-MB...

Background: The evaluation of pre-analytical, analytical and post-analytical phases is very important to obtain accurate, price and comparable results. Quality indicators are generally used to evaluate these processes. The present study aimed to evaluate the analytical phase...

Objective: Analytical reliability of clinical laboratories may be obtained by internal quality control, external quality control by analyzing the data with statistical methods. In Six Sigma Methodology, which is one of these methods, the analytical performance of the tests...

Aim: Sigmametric methodology is used as a quality management tool that predicts variables can be controlled and targets zero error.In this study, sigmametrics were calculated for some fertility function tests to pick the suitable quality control tools and approach for...

Objective: The cardiac troponins are sensitive and specific biochemical markers of myocardial damage. It has been suggested that hemolysis causes interference in the immunometric cardiac troponin assay. The current study aimed to determine the significance of hemolysis as an...

Objective: To compare the analytical performance of 2 immunoturbidimetric C-reactive protein (CRP) reagents using the same automated analyzer and to evaluate whether an alternative reagent provides clinically acceptable results.

Methods: This...

Aim: In this study, we aimed to evaluate the analytical process performance of clinical biochemistry parameters by six sigma method and to make the necessary arrangements according to the obtained results in our laboratory.

Material and Methods: In...

Aim: The aim of this study was to extensively evaluate four fully-automated photometric methods directly measuring antioxidant capacity; ferric ion reducing power, total antioxidant status, total antioxidant response, total thiol and to reveal the weak and strong sides of...

Purpose: Allowable total error (TEa) is an analytical quality specification setting acceptable limits for a single test result. It is used for sigmametric evaluation of test performance and description of control rules and measurement numbers. Total error of a test (TE)...

Aim: The measurement uncertainty (MU) of high-sensitivity troponin T (hs-TnT) and myoglobin assays was calculated in accordance with ISO/TS 20914:2019. The calculated MU values were subsequently compared with the relevant analytical performance specifications (APS).

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Objective: Use of C-Reactive protein in the follow-up of different clinical situations is getting more important. Levels of CRP can be detected by immunonephelometric and immunoturbidimetric methods in the clinical laboratories. The emergency departmentÕs laboratory renders...

Objectives: The aim of the study was to evaluate the analytical performance of the tests by calculating sigma values of some tests and to ensure that corrective actions were taken for the tests by presenting the differences between the sigma values calculated following...

There is no a standart pr ocedure to assess instrument quality on technical and analytical performance of glucometers yet. We made up our protocole considering NCCLS EP9-A2 (National Commitee for Clinical Laboratory Standarts EP9-A2) and ISO 15197 (International Organization for Standardization...

Objective: It has been proposed that the homocysteine (Hcy) produced during the metabolism of methionine plays a role in etiopathogenesis of several diseases. The interest in measurement of plasma Hcy levels has increased recently upon the finding that Hcy is an independent...

Aim: We aimed to demonstrate the interference in Hemoglobin A1c (HbA1c) testing in a patient diagnosed with Evans syndrome, a rare condition characterized by autoimmune hemolytic anemia.

Case: A patient who presented to our laboratory for biochemical...

Objective: Therapeutic drug monitoring for lithium therapy is important because of its narrow therapeutic range and non-specific nature of clinical findings of lithium toxicity. Methods such as ion-specific electrode (ISE), atomic absorption and flame emission have been used...

Objective: Measurement uncertainty is a useful method to obtain objective information about laboratory performance, to identify analytes that need analytical improvement in clinical use, and to abandon analytes of inadequate quality. The aim of the study was to calculate the...

Objective: Transferrin isoform analysis is performed for diagnosis of congenital or acquired defects in protein glycosylation. The reference method for transferrin isoform analysis is isoelectric focusing electrophoresis. The objective of this study has been to perform...

Aim: Measurement uncertainty provides information about the limits at which the measured value may vary as a result of random effects in a biochemical measurement. It is a quantitative indicator of the quality of the result obtained and allows us to estimate the extent to...

Objective: The present study examines the effect of hemolysis on serum sodium concentrations in hyponatremic and hypernatremic serum samples.

Material and Methods: Samples were assessed by three different sodium methods; direct ISE by means of dry...