Objective: Serum paraoxonase (PON1) is a HDL associated esterase and inhibits LDL oxidation. The oxidative modification of LDL plays an important role in the pathogenesis of atherosclerosis. In hemodialysis patients, the increased oxidative stress induces oxidative...

Objective: It is well known that chronic inflammation is an important factor of the process which leads to atherosclerosis. While leading to atherosclerosis inflammation can cause acute phase response as well. CRP, serologic indicator of inflamation, synthesized in liver, is...

Objective: Smoking is one of the most important cause of cardiovascular disease and known as a preventable risk factor. Lipoproteins especially LDL has an important role in cardiovascular disease. Normally high density lipoproteins protect LDL from oxidation; proinflammatory...

Objective: Sialic acid, known as a risk factor for coronary heart disease is also elevated in serum after myocardial infarction. Because acute myocardial infarction generally develops on the basis of atherosclerotic heart disease, the effect of experimental myocardial...

Purpose: In the recent years, the relationship between inflammation and atherosclerosis induced, which is a chronic inflammatory disease, acute coronary syndromes, including unstable angina and acute myocard infarction, has gained importance. Acute phase reactants, as...

Objective: Hyperphosphatemia and high calcium X phosphate product are significant and common risk factors of cardiovascular disease in patients with chronic kidney disease. However, the relationship is not clear between increased risk and hyperphosphatemia and elevated calcium...

Objective: Various algorithms for predicting coronary atherosclerosis have been established, most of which are based on large epidemiologic and cohort studies. We examined the predictive value of various clinical and biochem ical markers for angiographically defined coronary...

Objective: Atherosclerotic cardiovascular disease is the leading cause of the increased morbidity and mortality observed in uremic patients. The prevalance of cardiovascular diseases is high in the dialysis patients. Thrombosis is an important contributor to the evolution of...

Purpose: Rheumatoid arthritis (RA) is a chronic, progressive, autoimmune disease characterized by synovial inflammation, cartilage damage and bone erosion. Ischemia modified albumin (IMA) is a potential marker that can be used to assess atherosclerosis-related myocardial...

Objective: Defibrotide, a polydeoxyribonucleotide, has been found to modulate endothelial cell function and to have an antithrombotic effect on arteries, veins and capillaries. A significant amonut of evidence has been found about the protective role of defibrotide in...

Objective: ST-segment elevation myocardial infarction (STEMI) is an important cause of morbidity and mortality. Platelet (PLT) activation and thrombosis have important roles in the process of atherosclerosis that is one of the most important cause of acute ischaemic...

Objective: Elevated ischemia modified albumin (IMA) and C-reactive protein (CRP) levels have been reported as a result of ischemia, which is due to atherosclerosis and increased inflammatory processes. We measured serum CRP levels and ESR to determine inflammatory status of...

Dietary cholesterol is suggested to cause atherosclerosis and to increase the production of free radicals. It is reported that hypercholesterolemic diet may make some changes on the antioxidant system. In our study, we aimed to observe the effect of N-acetylcysteine (NAC) treatment on the...

Objective: Stroke, in all over the world, the one of the leading causes of morbidity and mortality especially in the geriatric population. Oxidative stress has an important role in pathophysiology of ischemic stroke. Malondialdehyde (MDA) is an important parameter of...

Fatty acid-binding proteins (FABPs) are abundant 14-15-kDa cytoplasmic proteins expressed in almost all mammalian tissues. They coordinate lipid responses in cells and related with metabolic and inflammatory pathways. FABPs bind to hydrophobic ligands, such as saturated and unsaturated long-chain...