The official publication of Turkish Society of Clinical Biochemistry
Objective: Glomerular filtration rate is one of the best indicators of renal function. It is usually determined indirectly by calculating renal clearance of endogenous filtration markers creatinine or urea. In addition, different formulas have been developed for determining...
Objective: Serum concentration of cystatin C is more reliable, specific and sensitive indicator for GFR, in comparison with serum creatinine concentration. This study is planned for the purpose of pointing out the utility of creatinine and cystatin C in evaluating the kidney...
Background: The purpose of this study was to investigate the superiority of serum cystatin C levels over serum urea and creatinine in evaluating kidney functions in intensive care unit patients.
Material and Methods: 65 patients in intensive care unit...
Aim: To evaluate urine integrity tests performed before illegal and abused substance analysis and to reveal their limitations.
Materials and Methods: This retrospective study was conducted between January 1, 2023 and June 15, 2023, in the AMATEM...
Background: It is thought that using a spot urine is more appropriate for microalbuminuria screening than 24 hours timed urine specimens due to collection and standardization difficulties. In this study, we examined the availability of spot urine as a screening test for the...
Objective: Low molecular weight proteins serum Cystatin C (sSC), β-2 Microglobulin (sβMg), Retinol Binding Protein (sRBP) have been proposed for estimation of Glomerular Filtration Rate (GFR). This study is designed to see how these proteins change with alterations of GFR in...
Objective: Analytical reliability of clinical laboratories may be obtained by internal quality control, external quality control by analyzing the data with statistical methods. In Six Sigma Methodology, which is one of these methods, the analytical performance of the tests...
Objective: N-acetyl-β-D-glucosaminadase (NAG) is a enzyme which exists in the lysosomes of renal proximal tubular cells. Increased NAG activity in urine is accepted as non-invasive early index of tubular damage. Lupus nephritis is known to be the most important complication of...
Objective: Cysta tin C has been proposed for the estimation of glomerular filtration rate (GFR). This study was designed to evaluate cystatin C levels in Type 2 Diabetes Mellitus (DM) as an early marker of diabetic nephropathy.
Materials and Methods:...
Objective: It has been reported that glucose intake creates changes at the levels of some electrolytes in serum and urine. The most important change observed in urine is the increase in calcium levels and this is thought to be the result of increased insulin levels in response...
Aim: Panic value refers to a laboratory test result that is life-threatening and requires immediate corrective action by the physician. Although there is no recommendation to re-run the panic-valued test, some laboratory specialists report the result after repeating the test....
Objective: The oxidative stress and renal vasoconstriction are considered to have an effect on the pathophysiology of contrast induced nephropathy. In this study, we aimed to evaluate the effects of contrast agents on serum creatinine, total antioxidant capacity and estimated...
Aim: Since glomerular filtration rate (GFR) determined by 24 hours urine is cumbersome, nephrologists recommend using an estimated GFR (eGFR). This study aimed to investigate the agreement between Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease...
Aim: The evaluation of biomarkers linked with inhibition and activation of vascular calcification in pre and post renal transplant period in renal transplant recipients was aimed in this research.Patients and
Methods: 35 recipients who had undergone...
Objective: Diabetic nephropathy is a major microvascular complication of diabetes, and it is responsible for 30-40% of all end-stage renal disease cases. Anemia is associated with various complications of diabetes, and its etiology is multifactorial. In this study, we...
Objective: In our study we aimed to investigate the role of fetuin-A, a systemic calcification inhibitor, and osteopontin, which plays an important role in calcification processes, in the pathogenesis of urinary tract stone disease.
Materials and Methods:...
Objective: A natural anticoagulant Protein C and its cofactor free Protein S, play an important role in the development of thrombosis in diabetics. In this study, we compared Protein C and Protein S concentrations in type 2 diabetic patients and healthy controls and observed...
Objective: Hyperphosphatemia and high calcium X phosphate product are significant and common risk factors of cardiovascular disease in patients with chronic kidney disease. However, the relationship is not clear between increased risk and hyperphosphatemia and elevated calcium...
Objective: The laboratory critical values are the laboratory testing results which required attention or action by the physicians. The aim of this study is to investigate the laboratory critical value notification process in our laboratory in terms of patient safety and...
Background: The evaluation of pre-analytical, analytical and post-analytical phases is very important to obtain accurate, price and comparable results. Quality indicators are generally used to evaluate these processes. The present study aimed to evaluate the analytical phase...
Objective: Although there have been many studies about the pre-analytic errors of hemolysis on laboratory tests, different results were found with different work environments and different methods. This study was put together to investigate the effects of hemolysis on routine...
Objective: In this study in which the purpose was to investigate the effect of hemodialysis treatment on cardiac markers and trace elements, serum copper, zinc, homocysteine and lipoprotein (a) levels and ceruloplasmin oxidase and adenosine deaminase activities and compared...
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