Özlem Gülbahar, Ayşe Banu Çaycı, İrem Budakoğlu, Uğur Erçin, Neslihan Bukan, Hatice Paşaoğlu, Tuncay Nas
Objective: Gestational diabetes mellitus is one of the most frequent complications in pregnancy which may create a health risk for the mother and the child. Different criteria may be used in the diagnosis of gestational diabetes mellitus. In the present study we aimed to test...
Journal of Turkish Clinical Biochemistry
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2010-08-01
Gülsüm Feyza Altaş, Sezer Uysal
Objective: The use of glycemic markers in the follow-up of Diabetes Mellitus is important to prevent the
development of complications. Glycated hemoglobin (HbA1c) is more stable and exhibits glucose status
of 8-12 weeks, while fasting plasma glucose (APG) reflects the...
Journal of Turkish Clinical Biochemistry
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2017-08-01
Gülben Sayılan Özgün, Sevgi Eskiocak, Necdet Süt
Objective: It has been reported that liver oxidative stress increases in streptozotocin induced experimental diabetes. The aim of this study is to investigate the effects of L-carnitine possessing antioxidant activity on liver protein oxidation seen in diabetes.
...
Journal of Turkish Clinical Biochemistry
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2012-04-01
Asuman Orçun, İnci Küçükercan, Özlem Çakır Madenci, Nuray Kolcu, Buket Tekçe
Early diagnosis and efficient therapy is essential for the prevention of micro and macrovascular complications of diabetes mellitus (DM). Different diagnostic criteria for DM have been proposed by different international organizations. In this study we compared criteia of "National Diabetes Data...
Journal of Turkish Clinical Biochemistry
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2003-08-01
Seda V. İrer, Gülinnaz Alper
In research studies performed to enlighten the diagnosis and pathogenesis of various diseases and to investigate possible treatment strategies, experimental animal models provide many advantages to the investigators. Diabetes Mellitus is a chronic metabolic disease which lasts for whole life,...
Journal of Turkish Clinical Biochemistry
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2004-12-01
Cemile Koca, Nilgün Altan, Aylin Sepici Dincel, Funda Kosova, Duygu Şahin, Metin Arslan
Objective: In this study, we aimed to evaluate the possible effects of leptin and oxidative stress on the pathogenesis of type 1 and type 2 diabetes mellitus.
Material and Methods: Subjects were assigned to four groups: type 1 diabetes group (n=20),...
Journal of Turkish Clinical Biochemistry
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2008-12-01
Giray Bozkaya, Emrah Özgü, Baysal Karaca, Onur Özgenç
Objective: Mean platelet volume (MPV) is a determinant of platelet function. Determining the MPV
levels is very important for the diabetic patients who have the risk of developing vascular diseases.
The aim of this study is to investigate any significant difference in the...
Journal of Turkish Clinical Biochemistry
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2008-04-01
Barış Sağlam, Sezer Uysal, Banu Önvural
Diabetes Mellitus (DM) is a very common chronical disease of our country. In diagnosis of DM and
monitoring of glycemic values, besides glucose,HbA1c is also being used. However HbA1c cannot reflect
glycemic levels for short term and also, conditions like anemia, hemoglobinopathies and chronic...
Journal of Turkish Clinical Biochemistry
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2014-08-01
Namık Delibaş, İbrahim Kılınç
Diabetes mellitus is a metabolic disease characterized by hyperglycemia resulting from defective insulin secretion or resistance to insulin action, or both. Production of sugar alcoholes called as metabolic hypothesis, ischemia-hipoxia oxidative stress, and insufficiency of neurotrophin or...
Journal of Turkish Clinical Biochemistry
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2003-04-01
Veysel Sucu, Sembol Yıldırmak, Mustafa Durmuşcan, Eren Vurgun, Osman Evliyaoğlu
Objective: Hemoglobin A1c levels which show the average level of blood glucose over the previous 3
months, have been used in the diagnosis and the follow-up of diabetes mellitus. Effect of iron deficiency
anemia which is the most common anemia, on hemoglobin A1c levels is...
Journal of Turkish Clinical Biochemistry
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2015-04-01
Gülfer Öztürk, Zeynep Giniş, Hülya Akdeniz, Tuncay Delibaşı, Namık Delibaş
Objective: Cysta tin C has been proposed for the estimation of glomerular filtration rate (GFR). This
study was designed to evaluate cystatin C levels in Type 2 Diabetes Mellitus (DM) as an early marker
of diabetic nephropathy.
Materials and Methods:...
Journal of Turkish Clinical Biochemistry
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2011-12-01
Sevil Kurban, İdris Mehmetoğlu
Conjugated linoleic acid (CLA) refers to a class of positional and geometric conjugated isomers of the omega-6 essential fatty acid, linoleic acid (LA). In 1987 anticancerogen properties of CLA were first discovered by Pariza and coworkers coincidentally. Since these early discoveries, an array...
Journal of Turkish Clinical Biochemistry
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2006-08-01
Inanc Karakoyun, Fatma Demet Arslan
Aim: Pancreatic cancer (PC) is a disease with complex and poorly understood etiology. One of the
common risk factors of PC is diabetes mellitus (DM). Increased carbohydrate antigen (CA) 19-9 levels
can be used as a biomarker in diagnosis of PC. However, CA 19-9 levels have...
Journal of Turkish Clinical Biochemistry
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2020-12-01
Çiğdem Karakükcü, Meral Mert, Ahmet Karaman
Objective: There is an increase in platelet activation in diabetics and patients with diabetic
complications. Labile hemoglobin A1c (LHbA1c), an early glycation product, can turn into other
glucose metabolites which can be responsible for many kinds of pathologies observed...
Journal of Turkish Clinical Biochemistry
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2011-12-01
Türkan Yiğitbaşı, Serkan Kap, Yasemin Baskın, Banu Aslan Şentürk, Nihal Kahya Eren, Füsun Üstüner, Oktay Ergene
Objective: Levels of C-reactive protein might be important, in coronary artery disease regarding
long-term risk assessment and prognosis. It has been showed that coronary artery disease is
associated with high levels of C-reactive protein whereas the relationship between...
Journal of Turkish Clinical Biochemistry
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2009-04-01
Işıl ÇAKIR
Aim: The frequency and severity of urinary tract infections (UTI) in diabetic patients are increasing.
HbA1c retrospectively gives important information about glycemic control. In this study it was aimed to
examine the relationships between presence of microscobic...
Journal of Turkish Clinical Biochemistry
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2020-08-01
Sibel Bilgili, Özge Fenercioğlu, Gizem Ercan, Giray Bozkaya
Purpose: Oral glucose tolerance test (OGTT) is a very important procedure in diagnosing diabetes
mellitus. It is very crucial to perform OGTT according to the rules that must be taken into account in
preparation period of the test. Our aim was to determine the level of...
Journal of Turkish Clinical Biochemistry
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2021-08-01
Tevfik Noyan, Ragıp Balahoroğlu, Ufuk Kömüroğlu
It has been reported that oxidative stress is increased in diabetes mellitus and the increase in oxidative stress gives rise to complications of this disease. In the present study, we aimed to investigate the effects of vitamin A, E, and C treatments combined with insulin on the oxidative and...
Journal of Turkish Clinical Biochemistry
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2004-12-01
Nihal Yücel, Filiz Eryarsoy, Neslihan Sağlam, Nazan Tunçbilek, Asuman Orçun
Objective: In this study, we investigated the relationship between androgen levels and type 2 diabetes in men and women.
Material and Methods: 99 diabetic patients receiving oral antidiabetic treatment, without any micro and macrovascular complications,...
Journal of Turkish Clinical Biochemistry
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2007-04-01
Nazan Tunçbilek, Asuman Orçun, Nuray Kolcu, Mehmet Sargın, İnci Küçükercan, Gülcan Baloğlu
Objective: A natural anticoagulant Protein C and its cofactor free Protein S, play an important role in the development of thrombosis in diabetics. In this study, we compared Protein C and Protein S concentrations in type 2 diabetic patients and healthy controls and observed...
Journal of Turkish Clinical Biochemistry
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2005-04-01
Sezer Uysal
Improving glycemic control reduces the development of microvascular and macrovascular
complications of diabetes mellitus. HbA1c measured by various methods is used to monitor glycemic
status. In 1990s, various national standardization programs were implemented to reduce variability in
HbA1c...
Journal of Turkish Clinical Biochemistry
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2011-12-01
Erkan Söğüt, Enver Avcı, Füsun Üstüner, Erdinç Arıkan
Objective: Various algorithms for predicting coronary atherosclerosis have been established, most of which are based on large epidemiologic and cohort studies. We examined the predictive value of various clinical and biochem ical markers for angiographically defined coronary...
Journal of Turkish Clinical Biochemistry
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2006-04-01
Suna Taşdemir Dündar, Sembol Yıldırmak, Cihan Dündar, Hatice Ayabakan, Hülya Cebeci Çerçi, Necati Yenice
Objective: Acute coronary syndromes (ACS) such as unstable angina, myocardial infarction, or sudden ischemic death evolve from coronary thrombosis and as a consequence of atherosclerotic plaque disruption. “Aspirin resistance” is a poorly defined term to describe the inability...
Journal of Turkish Clinical Biochemistry
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2007-08-01
Özben Özden Işıklar
Galectin-3 is a multifunctional protein that plays a critical role in inflammation, apoptosis, and fibrosis. It is considered a biomarker and therapeutic target in cardiovascular and neurodegenerative diseases, as well as pulmonary, hepatic, and renal fibrosis. Additionally, it is associated with...
Journal of Turkish Clinical Biochemistry
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2025-04-01
Giray Bozkaya, Murat Örmen
Purpose: Hemoglobin A1c (HbA1c), also known as glycated hemoglobin, indicates the blood glucose
control over the last 8-12 weeks. HbA1c level is a useful marker for the monitoring of the diabetic
patient and shows the necessity of any adjustment to the treatment has to be...
Journal of Turkish Clinical Biochemistry
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2018-08-01