Objective: It has been proposed that the homocysteine (Hcy) produced during the metabolism of methionine plays a role in etiopathogenesis of several diseases. The interest in measurement of plasma Hcy levels has increased recently upon the finding that Hcy is an independent...

Objective: HPLC (High Performance Liquid Chromatography) is the most commonly used method to differentiate the subtypes of hemoglobin in screening for hemoglobinopathy. Today, different models and trademarks of HPLC equipment have been used in screening for hemoglobinopathy....

Objective: Measurement of HbA1c is widely used in patients with diabetes mellitus as a monitor of retrospective glycemic control. Currently, more than 30 different methods are commercially available to measure HbA1c and these methods vary in the fraction of Hb measured and the...

Objective: Reduced glutathione is the most important antioxidant molecule of intracellular medium and a good marker for investigating antioxidant defence mechanism in diseases which are caused by oxidative stress. In this study we compared the spectrophotometric measurement...

Background: It has been established that hemoglobinopathies and chemically modified derivatives of hemoglobin, interfered with some HbA1c assay methods either positively or negatively. In this study we present a case with a low HbA1c value as measured by ion-exchange HPLC...

Aim: Beta thalassemias are common autosomal recessive inherited hemoglobinopathy worldwide. Hemoglobin A2 levels are the most important parameter used to determine beta-thalassemia carriers. One of the most commonly used methods for HbA2 measurement is high-performance...

Aim: Vitamin D deficiency is a common public health problem in our country. It is possible to find data reaching 90% in studies about determining deficiency prevalence. In recent years, this deficiency has been attracted the attention of the press and has directed people to...

Objective: Method comparison experiments are based on comparison of samples results analyzed by the new test method and previously accepted method. In this study is aimed to compare reversedphase cation exchange chromatography with boronate affinity chromatography method...

Aim: We aimed to demonstrate the interference in Hemoglobin A1c (HbA1c) testing in a patient diagnosed with Evans syndrome, a rare condition characterized by autoimmune hemolytic anemia.

Case: A patient who presented to our laboratory for biochemical...

Objective: High Performance Liquid Chromatography (HPLC) is widely used to classify hemoglobin fractions in screening of hemoglobinopathies. We, here in this study, detected the “measurement uncertainty” of the pivotal parameter in thalassemia screening, namely HbA2; and...

Objective: Hemoglobinopathies are an array of disorders that affect hemoglobin (Hb) function. HPLC is by far the most common technique used for detection of hemoglobinopathies worldwide. The aim of this study is to evaluate 3-year retrospective data of a tertiary hospital in...

HbA1c measurement was performed by the high-performance liquid chromatography (HPLC) method, and the result was measured as 3.5% (14.75 mmol/mol). Since the HbA1c result was inconsistent with the other clinical values of the patient, the same sample was run in the variant mode of the...

Aim: Method evaluation studies should be carried out for every new method planned to be used in laboratories. The aim of this study is to determine the analytical performance of the immunoassay method used for determining of plasma 25-hydroxy vitamin D levels and also to...

Objective: However, the analytical and standardization problems have continued, vitamin D status is usually assessed by measuring the plasma concentration of 25-hydroxyvitamin D [25(OH)D]. The aim of this study was to compared vitamin D levels of 50 healthy volunteers...

Objective: Thalassaemia among the hemoglobinopathies is a heterogenous group of disorders which transmitted autosomal recessive fashion and result from a reduced or no sythesis of one or more globin chains. Thalassaemias seen with high prevalance in a zone starting from...

Aim: In this study, it was aimed to examine the relationship between serum levels of neopterin, which is considered a marker of cellular immunity and oxidative stress, and the presence of H. pylori, which causes both inflammation and increased oxidative stress.

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Purpose: Hemoglobin A1c (HbA1c), also known as glycated hemoglobin, indicates the blood glucose control over the last 8-12 weeks. HbA1c level is a useful marker for the monitoring of the diabetic patient and shows the necessity of any adjustment to the treatment has to be...

Aim: We aimed to evaluate HbA1c with HbA0, HbF, HbA1 subfractions and to discuss the clinical usefulness of HbA1c by considering the total hemoglobin (THb) levels of the patients.

Materials and Methods: This retrospektif study included 338 individuals...

Objective: Prostate specific antigen (PSA) and ma ny other tumor markers are suggested to be useful for the biologic activity of the prostate cancer. The aim of our study is to investigate possible relationship between inflammatory markers (high sensitive C-Reactive Protein...

Aim: The aim was to determine if the malondialdehyde (MDA) and advanced oxidation products of protein (AOPPs) levels, which are oxidative stress parameters, can be used to determine the degree of coronary artery disease.

Materials and Methods: The...