Objective: However, the analytical and standardization problems have continued, vitamin D status is usually assessed by measuring the plasma concentration of 25-hydroxyvitamin D [25(OH)D]. The aim of this study was to compared vitamin D levels of 50 healthy volunteers...

Aim: Method evaluation studies should be carried out for every new method planned to be used in laboratories. The aim of this study is to determine the analytical performance of the immunoassay method used for determining of plasma 25-hydroxy vitamin D levels and also to...

Objective: High Performance Liquid Chromatography (HPLC) is widely used to classify hemoglobin fractions in screening of hemoglobinopathies. We, here in this study, detected the “measurement uncertainty” of the pivotal parameter in thalassemia screening, namely HbA2; and...

Objective: Thalassaemia among the hemoglobinopathies is a heterogenous group of disorders which transmitted autosomal recessive fashion and result from a reduced or no sythesis of one or more globin chains. Thalassaemias seen with high prevalance in a zone starting from...

Objective: The use of glycemic markers in the follow-up of Diabetes Mellitus is important to prevent the development of complications. Glycated hemoglobin (HbA1c) is more stable and exhibits glucose status of 8-12 weeks, while fasting plasma glucose (APG) reflects the...

Aim: Beta thalassemias are common autosomal recessive inherited hemoglobinopathy worldwide. Hemoglobin A2 levels are the most important parameter used to determine beta-thalassemia carriers. One of the most commonly used methods for HbA2 measurement is high-performance...

Objective: Anemia is a commonly encountered health problem. In this study, togetherness of beta thalassemia trait with iron deficiency anemia was investigated using by some biochemical and hematological cell count indices.

Material and Methods: The...

Objective: HPLC (High Performance Liquid Chromatography) is the most commonly used method to differentiate the subtypes of hemoglobin in screening for hemoglobinopathy. Today, different models and trademarks of HPLC equipment have been used in screening for hemoglobinopathy....

HbA1c measurement was performed by the high-performance liquid chromatography (HPLC) method, and the result was measured as 3.5% (14.75 mmol/mol). Since the HbA1c result was inconsistent with the other clinical values of the patient, the same sample was run in the variant mode of the...

Objective: Measurement of HbA1c is widely used in patients with diabetes mellitus as a monitor of retrospective glycemic control. Currently, more than 30 different methods are commercially available to measure HbA1c and these methods vary in the fraction of Hb measured and the...

Aim: Rheumatoid arthritis (RA) is an autoimmune disease and its etiology hasnt been fully elucidated. However, excessive amounts of reactive oxygen derivatives have been detected in the synovial fluids of patients with RA. Therefore, systemic inflammation and oxidative...

Aim: Raynaud's phenomenon is characterized by transient reduction in blood supply through the small arteries in the hands and feet. Secondary Raynaud's phenomenon accompanies collagen vascular diseases such as rheumatoid arthritis and scleroderma. The relationship between...

Objective: Reduced glutathione is the most important antioxidant molecule of intracellular medium and a good marker for investigating antioxidant defence mechanism in diseases which are caused by oxidative stress. In this study we compared the spectrophotometric measurement...

Aim: We aimed to demonstrate the interference in Hemoglobin A1c (HbA1c) testing in a patient diagnosed with Evans syndrome, a rare condition characterized by autoimmune hemolytic anemia.

Case: A patient who presented to our laboratory for biochemical...