Objective: The cardiac troponins are sensitive and specific biochemical markers of myocardial damage. It has been suggested that hemolysis causes interference in the immunometric cardiac troponin assay. The current study aimed to determine the significance of hemolysis as an...

Objective: Troponin I is a reliable and sensitive marker which is used to evaluate the myocardial injury. However there are different cut-off values for Troponin I due to different measurement technics. Therefore it is recommended that laboratories must define their own...

Aim: Measurement of cardiac troponins is of great importance in the diagnosis and follow-up of acute myocardial infarction. The diagnostic specificity of myocardial infarction has increased with algorithms including serial troponin measurements. It is important that the...

Aim: The measurement uncertainty (MU) of high-sensitivity troponin T (hs-TnT) and myoglobin assays was calculated in accordance with ISO/TS 20914:2019. The calculated MU values were subsequently compared with the relevant analytical performance specifications (APS).

...

High-sensitivity cardiac troponin T (hs-cTnT) assays are crucial in evaluating chest pain, but their increased sensitivity makes them susceptible to pre-analytical interferences. False-positive results may lead to unnecessary clinical interventions, especially in pediatric populationsa...

Objective: The synthesis of matrix metalloproteinase-1 (MMP-1) which is claimed to cause early mortal damage during the first moments of coronary reperfusion, is reported to be induced in-vitro by oxidized low density lipoprotein (LDL). The in- vivo changes in MMP-1, it's...

Purpose: Although most studies showed that the increase of cardiac biomarkers due to myocardial injury during coronavirus disease (COVID-19) is a strong predictor of adverse clinical events, few studies compared other causes of myocardial injury and COVID-19. In our study,...

Objective: Sialic acid, known as a risk factor for coronary heart disease is also elevated in serum after myocardial infarction. Because acute myocardial infarction generally develops on the basis of atherosclerotic heart disease, the effect of experimental myocardial...

Objective: Acute coronary syndrome (ACS) is a group of symptoms for acute myocardial ischemia. The RDW (red cell distribution width), recently described as a novel risk marker, has been associated with an increased risk of cardiovascular events and routinely reported as part...

Aim: Doxorubicin (DOXO) is a highly effective and extensively prescribed anticancer antracycline drug, however, its use is limited by multidrug resistance and dose-dependent cumulative cardiotoxicity. Administration of DOXO with widely used antidepressan fluoxetine (FLU) is...