Objective: Adiponectin, is a novel adipose tissue specific protein that has structural homology collagen VIII, X and complement factor C1q. It is also shown that insulin resistance and obesity cause to diminish adiponectin extraction from human adipose tissue but the...

Objective: The aim of the present study is to investigate the relation between new obesity indices waist circumference/height (WtHR), visceral adiposity index (VAI) and body adiposity index (BAI) and homeostasis model assessment of insülin resistance (HOMA-IR) index and...

Objective: In this study, we aimed to evaulate serum C-reactive protein (CRP), interleukin 6 (IL-6), and neopterin levels with lipoprotein phospholipase A2(Lp-PLA2) activity in obese adolescents with or without insulin resistance, and to demonstrate their relationships with...

Objective: Obesity promotes the development of diseases in many organ systems. The relationship between lipoporotein (a), lipid parameters and insulin resistance which accompany obesity has not been clarified. The correction of dyslipidemia in obesity and insulin resistance is...

Diabetes mellitus is a metabolic disease characterized by hyperglycemia resulting from defective insulin secretion or resistance to insulin action, or both. Production of sugar alcoholes called as metabolic hypothesis, ischemia-hipoxia oxidative stress, and insufficiency of neurotrophin or...

Objective: Plasminogen activator inhibitor type I (PAI-1) an inhibitor of fibrinolysis and an important and independent cardiovascular risk factor, has been shown to be elevated in obesity. The aim of this study was to evaluate plasma PAI-1 levels in obese subjects and to...

It has been reported that oxidative stress is increased in diabetes mellitus and the increase in oxidative stress gives rise to complications of this disease. In the present study, we aimed to investigate the effects of vitamin A, E, and C treatments combined with insulin on the oxidative and...

Objective: The aim of this study is to determine the correlation between insulin resistance and serum IL-8 levels of obese individuals with normal glucose tolerance.

Materials and Methods: 72 obese individuals with the ages ranging from 20 to 59 and...

Objectives: Despite various studies on the effect of thyroid status on insulin sensitivity in recent years, there are conflicting data. Thyroid dysfunction leads to changes in glucose and lipid metabolism, which is an important risk factor for cardiovascular diseases. For this...

Objective: It has been reported that glucose intake creates changes at the levels of some electrolytes in serum and urine. The most important change observed in urine is the increase in calcium levels and this is thought to be the result of increased insulin levels in response...

Aim: Pancreatic cancer (PC) is a disease with complex and poorly understood etiology. One of the common risk factors of PC is diabetes mellitus (DM). Increased carbohydrate antigen (CA) 19-9 levels can be used as a biomarker in diagnosis of PC. However, CA 19-9 levels have...

Aim: The aim of this study was (1) to compare the serum insulin, ghrelin, obestatin and, copeptin levels between pregnant and non-pregnant women and (2) investigate the changes in these parameters in pregnant women that measured at before and second hour after 75 gram (g)...

Objectives: Protein energy malnutrition and inflammation are among the causes of morbidity in patients with metabolic stress. Because of the adipogenic and somatotrophic effects of insulin, insulin like growth factor-1(IGF-1) and insulin like growth factor binding protein-3...

Objective: The discovery of vitamin D receptors and vitamin D activating enzymes in several cells other than those involved in bone and mineral metabolism brought the non-classical effects of vitamin D into focus. It was reported that diabetic patients have significantly...

Objective: The aim of this study is to research relations between first hour glucose and insuline level and inflamation markers in individuals who was loaded 75 grams glucose.

Materials and Methods: 11 individuals who were non obese and normal glucose...

Objective: In this study, we investigated the relationship between androgen levels and type 2 diabetes in men and women.

Material and Methods: 99 diabetic patients receiving oral antidiabetic treatment, without any micro and macrovascular complications,...

Aim: Polycystic ovarian syndrome (PCOS) is a multifactorial disorder with different phenotypic characteristics, the most frequent endocrine disorder in women, and the leading cause of anovulatory infertility. Kisspeptin is recognized to have a crucial function in regulating...

Objective: Metabolic syndrome is a comorbidity of insulin resistance, impaired glucose tolerance, abdominal obesity, hypertension and dyslipidemia and associated with increased risk of cardiovascular disease. The secretion of adipocytokines such as leptin and adiponectin...

Aim: Leptin is a nonglycolyzed peptide, made of 146amino-acids, that is produced by ob-gene in fat tissue. Leptin in circulation shows its effects by inhibiting Neuropeptide-Y in central nervous system and shows its effects on body fat mass by decreasing appetite and...

Fatty acid-binding proteins (FABPs) are abundant 14-15-kDa cytoplasmic proteins expressed in almost all mammalian tissues. They coordinate lipid responses in cells and related with metabolic and inflammatory pathways. FABPs bind to hydrophobic ligands, such as saturated and unsaturated long-chain...

Objective: In this study, we aimed to investigate the importance of serum pregnancy associated plasma protein A (PAPP-A) levels as an early marker before an acute myocardial infarction due to a high risk atherosclerotic plaque rupture and the relationship between PAPP-A and...

Our aim was to investigate the role of serum leptin levels in the control of fat mass in Professional athletes. 7 female and 7 male athletes were included in this study. Test subjects have been active in sports life for 2 years. First blood samples were taken at the period when athletes prior...

Objective: Pre-eclampsia is a pregnancy specific form of hypertension and a multisystem disorder of maternal and placental origin. Pregnancy associated plasma protein-A (PAPP-A) is a insulin like growth factor binding protein 4- degrading metalloproteinase. The aim of this...

Aim: Quality improvement studies in clinical laboratories play a vital role in achieving accurate and reliable patient results. Measurement uncertainty is important for the quality and reliability of test results. Since laboratory results inherently involve uncertainty, ISO...

Objective: Obesity is the leading public health problem in this century. In this study we aimed to evaluate the hsCRP levels which are the indicators of inflammation in obese people (defined with BMI) and assess the relation between obesity and hsCRP.

Materials...