The official publication of Turkish Society of Clinical Biochemistry
Objective: Use of C-Reactive protein in the follow-up of different clinical situations is getting more important. Levels of CRP can be detected by immunonephelometric and immunoturbidimetric methods in the clinical laboratories. The emergency departmentÕs laboratory renders...
Aim: In this study, we aimed to evaluate the analytical process performance of clinical biochemistry parameters by six sigma method and to make the necessary arrangements according to the obtained results in our laboratory.
Material and Methods: In...
Purpose: Nitric oxide(NO) is one of the important substances that are synthesized to keep the blood vessels dilated enough to provide adequate flow and to maintain cerebrovascular homeostasis. Creactive protein(CRP) is a highly sensitive indicator of inflammation and tissue...
Objective: In this study, we aimed to investigate the importance of serum pregnancy associated plasma protein A (PAPP-A) levels as an early marker before an acute myocardial infarction due to a high risk atherosclerotic plaque rupture and the relationship between PAPP-A and...
Aim: In this study, we compared 3 different clot-activator gel tubes to a glass reference tube and evaluated the effect of storage time on 30 different biochemical analytes.
Material and Methods: Blood samples were collected in 4 types of tubes: an...
Purpose: In the recent years, the relationship between inflammation and atherosclerosis induced, which is a chronic inflammatory disease, acute coronary syndromes, including unstable angina and acute myocard infarction, has gained importance. Acute phase reactants, as...
Objective: Obesity is the leading public health problem in this century. In this study we aimed to evaluate the hsCRP levels which are the indicators of inflammation in obese people (defined with BMI) and assess the relation between obesity and hsCRP.
Materials...
Objective: To compare the analytical performance of 2 immunoturbidimetric C-reactive protein (CRP) reagents using the same automated analyzer and to evaluate whether an alternative reagent provides clinically acceptable results.
Methods: This...
Objective: In recent years hsCRP and procalcitonin has started to be used in diagnosis and assessment of the prognosis of cardiovascular diseases. In this study we aimed to evaluate the prognostic significance of alterations in C-reactive protein (CRP) and procalcitonin...
Objective: Low molecular weight proteins serum Cystatin C (sSC), β-2 Microglobulin (sβMg), Retinol Binding Protein (sRBP) have been proposed for estimation of Glomerular Filtration Rate (GFR). This study is designed to see how these proteins change with alterations of GFR in...
Aim: The uncertainty of measurement is an important indicator for both the expediency of a method and the reliability of analytical results obtained in a laboratory. Accreditation processes such as ISO 15189 also expect laboratories to have a defined method for measurement...
Objective: The aim of this study is to examine the effect of hypeglycemic peak induced by OGTT on the basal inflammatory state by exploring the serum CRP level diffferencesMaterial and
Methods: I24 patients for suspicous of diabetes who have applied...
Objective: The increase in serum procalcitonin (PCT) levels is a marker of severe systemic inflammation due to bacterial infection and renal excretion plays an important role in its elimination. The aim of this retrospective study is to investigate the relationship between...
Objective: Preeclampsia is characterized with edema, proteinuria and hypertension and develops after the 20th week of pregnancy and seen only in pregnancy. In preeclampsia vasospastic ischemia and hypertension can lead to brain, liver and renal infarction. One of the renal...
Objective: Diabetic nephropathy is a major microvascular complication of diabetes, and it is responsible for 30-40% of all end-stage renal disease cases. Anemia is associated with various complications of diabetes, and its etiology is multifactorial. In this study, we...
Aim: The aim of this study is to investigate the possible effects of chronic smoking on serum vitamin D and some inflammation markers.
Materials and Methods: The smoking history of a total of 110 volunteer adults, 76 females and 34 males, for whom 25...
Objective: Ankylosing spondilitis (AS) is a chronic inflammatory disease involving primarily the skeletal system, the peripheral joints and extra-articular structures. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are commonly used assays for measuring...
Objective: The aim of this study is to determine the new median values of biochemical analytes used in double and triple prenatal screening tests and to compare these values with the median values of the package program used in screening tests.
Materials and...
Objective: The synthesis of matrix metalloproteinase-1 (MMP-1) which is claimed to cause early mortal damage during the first moments of coronary reperfusion, is reported to be induced in-vitro by oxidized low density lipoprotein (LDL). The in- vivo changes in MMP-1, it's...
Objective: Autoimmunity is an important factor in the pathogenesis of Behcet Disease emphasized in recent years In recent studies, Vitamin D has been demonstrated to play a significant role in immune system functioning. The measurement of plasma 25-hydroxyvitamin D3levels,...
Objective: The purpose of this study is to determine the median values of the double test screening parameters in Bursa region and to reevaluate the test results positive risky pregnancies according to previous computer programme.
Materials and Methods:...
Aim: To investigate the presence of oxidative stress and dyslipidemia, which increase cardiovascular risk, and the effect of gonadotropin replacement therapy on these parameters in patients with Idiopathic Hypogonadotropic Hypogonadism (IHH).
Material and...
Fully Diamond OA with no APCs and no submission fees. Your research is freely available to readers worldwide from the day it publishes.
Double-blind peer review from an active editorial team returns a first decision in about 30 days, keeping your manuscript moving.
Backed by the Turkish Society of Clinical Biochemistry, JTCB welcomes submissions from researchers worldwide and reaches an international laboratory audience.
Method validation, analyzer comparisons, reference intervals, quality indicators, preanalytical studies, and instructive clinical case reports.
All manuscripts publish in English and follow ICMJE and COPE guidelines, with Crossref DOIs and TR Dizin indexing ensuring global discoverability.