The official publication of Turkish Society of Clinical Biochemistry
Objective: Cardiovascular diseases (CVD) are the leading causes of death worldwide. After understanding the importance of inflammation in the pathogenesis, CRP usage has been increased for the determination of cardiovascular risk. As an inflammation marker, the relationship...
Background: Cold agglutinin disease; is a rare autoimmune hemolytic anemia caused by IgM antibodies (rarely IgA or IgG) against polysaccharide antigens on erythrocytes at low temperatures. As the cold activated antibodies cause degeneration and autoagglutination in the...
Aim: The evaluation of biomarkers linked with inhibition and activation of vascular calcification in pre and post renal transplant period in renal transplant recipients was aimed in this research.Patients and
Methods: 35 recipients who had undergone...
Aim: We aimed to reveal the potential roles of periostin, hypoxia-inducible factor-1α (HIF-1α), and phospholipase A2 (PLA2) in inflammation, hypoxia, and tissue damage in patients with coronavirus disease 2019 (COVID-19) and to investigate whether they are useful potential...
Background: First trimester prenatal screening gives the risk rates associated with aneuploidies. Measurement uncertainty is defined as a magnitude showing distribution of the measured values. The aim of this study is to investigate the effects of measurement uncertainty on...
Aim: To determine the current median values for hormone parameters used in first trimester screening test for Kayseri province and to compare the median values with those in the software used for reporting of screening test and those detected for other regions found with...
Aim: We aimed to determine the glypican-3 levels in patients diagnosed with COVID-19, compare these values with the healthy controls, and analyze the evaluation of glypican-3 levels with inflammatory markers, including interleukin-6 (IL-6), to determine its role in disease...
Background: The evaluation of pre-analytical, analytical and post-analytical phases is very important to obtain accurate, price and comparable results. Quality indicators are generally used to evaluate these processes. The present study aimed to evaluate the analytical phase...
Objective: Preeclampsia is characterized with edema, proteinuria and hypertension and develops after the 20th week of pregnancy and seen only in pregnancy. In preeclampsia vasospastic ischemia and hypertension can lead to brain, liver and renal infarction. One of the renal...
Objective: Diabetic nephropathy is a major microvascular complication of diabetes, and it is responsible for 30-40% of all end-stage renal disease cases. Anemia is associated with various complications of diabetes, and its etiology is multifactorial. In this study, we...
Aim: The aim of this study is to investigate the possible effects of chronic smoking on serum vitamin D and some inflammation markers.
Materials and Methods: The smoking history of a total of 110 volunteer adults, 76 females and 34 males, for whom 25...
Objective: Ankylosing spondilitis (AS) is a chronic inflammatory disease involving primarily the skeletal system, the peripheral joints and extra-articular structures. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are commonly used assays for measuring...
Objective: The aim of this study is to determine the new median values of biochemical analytes used in double and triple prenatal screening tests and to compare these values with the median values of the package program used in screening tests.
Materials and...
Objective: The synthesis of matrix metalloproteinase-1 (MMP-1) which is claimed to cause early mortal damage during the first moments of coronary reperfusion, is reported to be induced in-vitro by oxidized low density lipoprotein (LDL). The in- vivo changes in MMP-1, it's...
Objective: Autoimmunity is an important factor in the pathogenesis of Behcet Disease emphasized in recent years In recent studies, Vitamin D has been demonstrated to play a significant role in immune system functioning. The measurement of plasma 25-hydroxyvitamin D3levels,...
Objective: The purpose of this study is to determine the median values of the double test screening parameters in Bursa region and to reevaluate the test results positive risky pregnancies according to previous computer programme.
Materials and Methods:...
Aim: To investigate the presence of oxidative stress and dyslipidemia, which increase cardiovascular risk, and the effect of gonadotropin replacement therapy on these parameters in patients with Idiopathic Hypogonadotropic Hypogonadism (IHH).
Material and...
Objectives: Urine specimen determinations sometimes may not be done immediately and may be studied by using urine strips which are ke pt in open air during routine work due to the conditions of study. In this study, the performance characteristics of urine strips and the...
Aim: Six Sigma methodology used in clinical laboratories is a quality management tool based on statistical calculations, focusing on process variables and providing information about process performance. In this study, we aimed to evaluate the analytical process performances...
Objective: Combine test (between the 11 th and 14th weeks of gestation) and triple test (between the 16 th and 18th weeks of gestation) are being used for trisomy 21 and trisomy 18 screening. We have investigated the precision of fetal nuchal translucency (NT), free β HCG...
Objective: Since the emergence of Coronavirus Disease 2019 (Covid-19) in December 2019, it has turned into a pandemic. Covid-19 infection; can trigger pulmonary inflammation and also cause acute lung injury. In cases with severe pneumonia, long hospital stays and high...
Aim: Crohn's disease (CD) is an immunity-based inflammatory disease of unknown etiology which affects any region of the gastrointestinal tract with transmural involvement. In these patients; many clinical activity indicators and noninvasive markers have been used to assess...
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