Aim: Method evaluation studies should be carried out for every new method planned to be used in laboratories. The aim of this study is to determine the analytical performance of the immunoassay method used for determining of plasma 25-hydroxy vitamin D levels and also to...

Aim: The aim of this study was to extensively evaluate four fully-automated photometric methods directly measuring antioxidant capacity; ferric ion reducing power, total antioxidant status, total antioxidant response, total thiol and to reveal the weak and strong sides of...

Aim: Point Of Care (POC) tests are quick tests that shorten the treatment period and are portable devices, which are easy to use for non-laboratory personnel. In this study we aimed to compare the results of INR (International Normalized Ratio) that were studied with POC...

Objective: Method comparison experiments are based on comparison of samples results analyzed by the new test method and previously accepted method. In this study is aimed to compare reversedphase cation exchange chromatography with boronate affinity chromatography method...

Screening for fecal occult blood has been shown to be effective in reducing the colorectal cancer mortality. Guaiac-based tests are one of the most frequently used screening tests, but their false positivity and negativity rates are quite high. Peroxidase enzyme, found in many fruits and...

Aim: /b> In this study, we evaluated the analytical performance and diagnostic adequacy of the activity and mass methods used for the measurement of CK-MB, a laboratory marker for the diagnosis of acute myocardial infarction (AMI). In addition, the differences between CK-MB...

Purpose: The measurement of serum ferritin is used as a reliable and noninvasive method for the monitoring of iron stores. There are many different methods for the ferritin measurement. However, the immunoturbidimetric method that having the less cost and possibility of the...

Purpose: In recent decades, several new techniques for measuring erytrocyte sedimentation rate have been developed in clinical laboratories. The aim of this study to compare three different automated sedimentation analyzers (Micro TEST-1, Sedisystem, Sed Rate Screener) with...

Aim: Vitamin D deficiency is a common public health problem in our country. It is possible to find data reaching 90% in studies about determining deficiency prevalence. In recent years, this deficiency has been attracted the attention of the press and has directed people to...

Objective: Graves' disease is an autoimmune disease which results in excessive production of thyroid hormones and is the most common cause of hyperthyroidism. TRAb has a key role to confirm the clinical diagnosis of Graves' disease. The different measurement methods have...

Objective: Comparison of two patient-side glucometers, Accuchek Active (AC) and Optium Xceed (OP)with autoanalyzer Olympus AU 2700 (OL), which uses the reference method.

Materials and Methods: 44 patients, aged over 18, who attended emergency and...

Purpose: The correct analysis of types and amounts of amino acids is highly important in the diagnosis of inborn errors of metabolism. The results obtained from heel blood drop and plasma of patients who were referred from primary health care institutions with pre-diagnosis...

Objective: In quantitative analysis of serum proteins turbidimetric and nephelometric methods are the most common. Aim of this study was to compare the nephelometric method with the turbidimetric method for serum and urine samples in our clinical laboratory and to analyse...

µ-FADU (Fluorometric Analysis of DNA Unwinding) and COMET are methods developed for the rapid detection of DNA damage and repair capacity. Both are based on time dependent alkaline DNA unwinding under appropriate denaturing conditions. COMET and µ-FADU are fluorometric and spectroflurometric...

Objective: Reduced glutathione is the most important antioxidant molecule of intracellular medium and a good marker for investigating antioxidant defence mechanism in diseases which are caused by oxidative stress. In this study we compared the spectrophotometric measurement...

Objective: In the clinical laboratories, the same test could be analyzed by more than one assay system or analyzer due to various requirements. This may cause a problem in patient monitoring. In our laboratory, stat TSH testing has been recently implemented in the stat...

Aim: This study aimed to evaluate the performance characteristics of preliminary coagulation tests on the Sysmex CS-5100 coagulation autoanalyzer and compare it with the ACL Top 700 autoanalyzer. Both analyzers were assessed for their ability to measure prothrombin time (PT),...

Aim: Erythrocyte sedimentation rate is useful for diagnosis and follow up of diseases such as infections, inflamm atory diseases, traumatologic disorders and several cancer types. In this study, we compared ESR results of classical Westergren method and Test-1 analyser which...

Objective: Measurement of HbA1c is widely used in patients with diabetes mellitus as a monitor of retrospective glycemic control. Currently, more than 30 different methods are commercially available to measure HbA1c and these methods vary in the fraction of Hb measured and the...

Objective: If a new analyzer in the laboratories is considered to be used, method comparison should be done. Two analyzers should be compared in order to evaluate accuracy of the new analyzer. In our study, we aimed to compare the performance of new coagulation analyzer with...

Objective: The accurate and reliable measurement of addictive substances is a very serious problem all over the world because it involves some legal liabilities. This study aims to measure the popular addictive substances using two common techniques and to reveal against...

Objective: However, the analytical and standardization problems have continued, vitamin D status is usually assessed by measuring the plasma concentration of 25-hydroxyvitamin D [25(OH)D]. The aim of this study was to compared vitamin D levels of 50 healthy volunteers...

Objective: C-reactive protein (CRP) is one of acute phase respondents that has been used to monitor infection and inflammation episodes. In our hospitals' emergency laboratory, CRP analysis is done with a point of care testing device (i-chroma). In our central biochemistry...

Background: Bromcresol green (BCG) and Bromcresol Purple (BCP) which are dye-binding based methods are widely used in serum albumin analysis in clinical laboratories for many years. It was suggested that discrepancies exist between these methods and these discrepancies are...

Objective: HPLC (High Performance Liquid Chromatography) is the most commonly used method to differentiate the subtypes of hemoglobin in screening for hemoglobinopathy. Today, different models and trademarks of HPLC equipment have been used in screening for hemoglobinopathy....