Objective: Various algorithms for predicting coronary atherosclerosis have been established, most of which are based on large epidemiologic and cohort studies. We examined the predictive value of various clinical and biochem ical markers for angiographically defined coronary...

Objective: Serum paraoxonase (PON1) is a HDL associated esterase and inhibits LDL oxidation. The oxidative modification of LDL plays an important role in the pathogenesis of atherosclerosis. In hemodialysis patients, the increased oxidative stress induces oxidative...

Objective: It is well known that chronic inflammation is an important factor of the process which leads to atherosclerosis. While leading to atherosclerosis inflammation can cause acute phase response as well. CRP, serologic indicator of inflamation, synthesized in liver, is...

Objective: Smoking is one of the most important cause of cardiovascular disease and known as a preventable risk factor. Lipoproteins especially LDL has an important role in cardiovascular disease. Normally high density lipoproteins protect LDL from oxidation; proinflammatory...

Objectives: Despite various studies on the effect of thyroid status on insulin sensitivity in recent years, there are conflicting data. Thyroid dysfunction leads to changes in glucose and lipid metabolism, which is an important risk factor for cardiovascular diseases. For this...

Objective: HDL is considered as anti-atherogenic and it exerts this effect with reverse cholesterol transport and with the contribution of enzymes such as paraoxonase and platelet activating factor acetylhydrolase. Data on biological variation can be used to determine the...

Objective: The prevalence of coronary artery disease is much higher in men than in women and sex hormones might play a role in these differences via their influence on lipid profile. However, the role of sex hormones in the relationship between male gender and cardiovascular...

Objective: Subclinical and cli nical hypothyroidism are relatively common endocrine disorders in the general population. Subclinical hypothyroidism is defined as an elevated serum thyroid stimulating hormone (TSH) level associated with normal total or free T4 (fT4) and T3...

Objective: The aim of this study was to evaluate serum total, HDL and LDL cholesterol and triglyceride levels and nitric oxide (NO) levels in rats with dietary walnut consumption.

Materials and Methods: The rats were divided into 2 groups as a control...

Objective: In addition to important roles of vitamin D on regulation of bone and mineral metabolism, recent studies have shown that Vitamin D is necessary for many biological actions. The aim of this study was to determine whether Vit D levels have any effects on lipid...

Aim: Lipid profile is used to determine the risk of cardiovascular diseases (CVD) and to monitor treatment. Reference change value (RCV) represents the clinical significance of the variation between the results of two consecutive tests and laboratory test results exceeding...

Objective: In this study, we aimed to evaulate serum C-reactive protein (CRP), interleukin 6 (IL-6), and neopterin levels with lipoprotein phospholipase A2(Lp-PLA2) activity in obese adolescents with or without insulin resistance, and to demonstrate their relationships with...

Purpose: The aim of the present study was to investigate the effects of taurine on plasma paraoxonase, arylesterase and lactonase activities in streptozotocin-induced experimental diabetes.

Materials and Methods: Thirty-six Sprague-Dawley female rats,...

Aim: The present study aimed to determine the reference range values for four lipid parameters associated with chronic diseases that were routinely examined in our laboratory in elderly individuals aged ≥65 years.

Materials and Methods: We determined...

Objectives: Protein energy malnutrition and inflammation are among the causes of morbidity in patients with metabolic stress. Because of the adipogenic and somatotrophic effects of insulin, insulin like growth factor-1(IGF-1) and insulin like growth factor binding protein-3...

Purpose: Laboratory tests are very important for diagnosis and tracking of disease and usage of laboratory testing has rised with each passing day. Unnecessary laboratory testing is one of the main reasons for increased laboratory use. In this study, we aimed to...

Our aim was to investigate the role of serum leptin levels in the control of fat mass in Professional athletes. 7 female and 7 male athletes were included in this study. Test subjects have been active in sports life for 2 years. First blood samples were taken at the period when athletes prior...

Aim: In this study, we aimed to evaluate the analytical process performance of clinical biochemistry parameters by six sigma method and to make the necessary arrangements according to the obtained results in our laboratory.

Material and Methods: In...

Objective: Metabolic syndrome is a comorbidity of insulin resistance, impaired glucose tolerance, abdominal obesity, hypertension and dyslipidemia and associated with increased risk of cardiovascular disease. The secretion of adipocytokines such as leptin and adiponectin...

Objective: The goal of this study was to investigate the correlation between the ultrasonographic measurements of subcutaneous adipose tissue thickness and serum lipid levels.

Materials and methods: Randomly selected 100 subjects (50 males and 50...

Objective: Adiponectin, is a novel adipose tissue specific protein that has structural homology collagen VIII, X and complement factor C1q. It is also shown that insulin resistance and obesity cause to diminish adiponectin extraction from human adipose tissue but the...

Objective: In this study in which the purpose was to investigate the effect of hemodialysis treatment on cardiac markers and trace elements, serum copper, zinc, homocysteine and lipoprotein (a) levels and ceruloplasmin oxidase and adenosine deaminase activities and compared...

Aim: Six Sigma methodology used in clinical laboratories is a quality management tool based on statistical calculations, focusing on process variables and providing information about process performance. In this study, we aimed to evaluate the analytical process performances...

Aim: To investigate the presence of oxidative stress and dyslipidemia, which increase cardiovascular risk, and the effect of gonadotropin replacement therapy on these parameters in patients with Idiopathic Hypogonadotropic Hypogonadism (IHH).

Material and...