Aim: Lipid profile is used to determine the risk of cardiovascular diseases (CVD) and to monitor treatment. Reference change value (RCV) represents the clinical significance of the variation between the results of two consecutive tests and laboratory test results exceeding...

Objective: It is well known that chronic inflammation is an important factor of the process which leads to atherosclerosis. While leading to atherosclerosis inflammation can cause acute phase response as well. CRP, serologic indicator of inflamation, synthesized in liver, is...

Objective: We aimed to investigate the possible differences between the analytical assay and estimation with Friedewald formula of LDL cholesterol in patients divided into subgroups according to direct LDL cholesterol, triglyceride, total cholesterol levels,...

Objective: Various algorithms for predicting coronary atherosclerosis have been established, most of which are based on large epidemiologic and cohort studies. We examined the predictive value of various clinical and biochem ical markers for angiographically defined coronary...

Dietary cholesterol is suggested to cause atherosclerosis and to increase the production of free radicals. It is reported that hypercholesterolemic diet may make some changes on the antioxidant system. In our study, we aimed to observe the effect of N-acetylcysteine (NAC) treatment on the...

Objective: The prevalence of coronary artery disease is much higher in men than in women and sex hormones might play a role in these differences via their influence on lipid profile. However, the role of sex hormones in the relationship between male gender and cardiovascular...

Objective: In addition to important roles of vitamin D on regulation of bone and mineral metabolism, recent studies have shown that Vitamin D is necessary for many biological actions. The aim of this study was to determine whether Vit D levels have any effects on lipid...

Objective: Levels of C-reactive protein might be important, in coronary artery disease regarding long-term risk assessment and prognosis. It has been showed that coronary artery disease is associated with high levels of C-reactive protein whereas the relationship between...

The direct link between cardiovascular disease and plasma cholesterol levels has been clearly described. Therapeutic interventions for lowering plasma cholesterol levels have a great significance in prevention of cardiovascular diseases. In enterocytes, numerous transport molecules in charge...

Objective: The aim of this study was to evaluate serum total, HDL and LDL cholesterol and triglyceride levels and nitric oxide (NO) levels in rats with dietary walnut consumption.

Materials and Methods: The rats were divided into 2 groups as a control...

Objective: The goal of this study was to investigate the correlation between the ultrasonographic measurements of subcutaneous adipose tissue thickness and serum lipid levels.

Materials and methods: Randomly selected 100 subjects (50 males and 50...

Objective: It has been known that levels of GGT might be important, in coronary artery disease for long-term risk assessment and determining prognosis. Relationship between coronary artery disease and levels of GGT was found whereas relationship severity of coronary artery...

Objective: Defibrotide, a polydeoxyribonucleotide, has been found to modulate endothelial cell function and to have an antithrombotic effect on arteries, veins and capillaries. A significant amonut of evidence has been found about the protective role of defibrotide in...

Objective: Obesity promotes the development of diseases in many organ systems. The relationship between lipoporotein (a), lipid parameters and insulin resistance which accompany obesity has not been clarified. The correction of dyslipidemia in obesity and insulin resistance is...

Objective: In this study in which the purpose was to investigate the effect of hemodialysis treatment on cardiac markers and trace elements, serum copper, zinc, homocysteine and lipoprotein (a) levels and ceruloplasmin oxidase and adenosine deaminase activities and compared...

Objective: Hyperphosphatemia and high calcium X phosphate product are significant and common risk factors of cardiovascular disease in patients with chronic kidney disease. However, the relationship is not clear between increased risk and hyperphosphatemia and elevated calcium...

Objectives: Despite various studies on the effect of thyroid status on insulin sensitivity in recent years, there are conflicting data. Thyroid dysfunction leads to changes in glucose and lipid metabolism, which is an important risk factor for cardiovascular diseases. For this...

Objective: Subclinical and cli nical hypothyroidism are relatively common endocrine disorders in the general population. Subclinical hypothyroidism is defined as an elevated serum thyroid stimulating hormone (TSH) level associated with normal total or free T4 (fT4) and T3...

Objective: HDL is considered as anti-atherogenic and it exerts this effect with reverse cholesterol transport and with the contribution of enzymes such as paraoxonase and platelet activating factor acetylhydrolase. Data on biological variation can be used to determine the...

Aim: In this study, we aimed to evaluate the analytical process performance of clinical biochemistry parameters by six sigma method and to make the necessary arrangements according to the obtained results in our laboratory.

Material and Methods: In...

Objective: In this study, we aimed to evaulate serum C-reactive protein (CRP), interleukin 6 (IL-6), and neopterin levels with lipoprotein phospholipase A2(Lp-PLA2) activity in obese adolescents with or without insulin resistance, and to demonstrate their relationships with...

Objective: Adiponectin, is a novel adipose tissue specific protein that has structural homology collagen VIII, X and complement factor C1q. It is also shown that insulin resistance and obesity cause to diminish adiponectin extraction from human adipose tissue but the...

Purpose: Laboratory tests are very important for diagnosis and tracking of disease and usage of laboratory testing has rised with each passing day. Unnecessary laboratory testing is one of the main reasons for increased laboratory use. In this study, we aimed to...

Objective: Plasminogen activator inhibitor type I (PAI-1) an inhibitor of fibrinolysis and an important and independent cardiovascular risk factor, has been shown to be elevated in obesity. The aim of this study was to evaluate plasma PAI-1 levels in obese subjects and to...

Background: The evaluation of pre-analytical, analytical and post-analytical phases is very important to obtain accurate, price and comparable results. Quality indicators are generally used to evaluate these processes. The present study aimed to evaluate the analytical phase...