Yakup Dülgeroğlu, Gökhan Bilgehan
Aim: In this study, it was aimed to examine the relationship between serum levels of neopterin, which is considered a marker of cellular immunity and oxidative stress, and the presence of H. pylori, which causes both inflammation and increased oxidative stress.
...
Journal of Turkish Clinical Biochemistry
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2023-08-01
Belgin Şenol, Ceyda Kabaroğlu, Saliha Aksun, Sara Habif, Işıl Mutaf, Nevbahar Turgan, Dilek Özmen, Hakan Kültürsay
Purpose: In the recent years, the relationship between inflammation and atherosclerosis induced, which is a chronic inflammatory disease, acute coronary syndromes, including unstable angina and acute myocard infarction, has gained importance. Acute phase reactants, as...
Journal of Turkish Clinical Biochemistry
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2003-12-01
Güneş Başol, Burcu Barutçuoğlu, A. Erkin Bozdemir
Hepcidin, a recently discovered peptide hormone, is the homeostatic regulator of intestinal iron absorption, iron recycling by macrophages and iron mobilization from hepatic stores. Hepcidin inhibits the cellular efflux of iron by binding to and inducing the degradation of ferroportin. Hepcidin...
Journal of Turkish Clinical Biochemistry
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2007-12-01
Muzaffer Katar, Şafak Şahin
Background: NAMPT/visfatin increases inflammation and its serum levels are affected in chronic lowgrade
inflammation such as autoimmune disorders, and thyroid cancers.
Aim: We aimed showing how NAMPT/visfatin levels are affected in Hashimotos...
Journal of Turkish Clinical Biochemistry
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2021-12-01
Duygu Eryavuz Onmaz, Abdullah Sivrikaya, Sedat Abuşoğlu, Sema Yılmaz, Ali Ünlü
Aim: Rheumatoid arthritis (RA) is an autoimmune disease and its etiology hasnt been fully elucidated.
However, excessive amounts of reactive oxygen derivatives have been detected in the synovial fluids of
patients with RA. Therefore, systemic inflammation and oxidative...
Journal of Turkish Clinical Biochemistry
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2021-12-01
Belkız Öngen İpek, Mustafa Erinç Sitar
Objective: For this current study, our aims were to investigate the relationships between HbA1c with
neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) which are accepted as new
markers of systemic inflammation and the relationships between HbA1c with CRP...
Journal of Turkish Clinical Biochemistry
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2018-08-01
Rabia Nur Kocabaş, A. Erkin Bozdemir, Güneş Başol, Burcu Barutçuoğlu, Zuhal Parıldar, Ceyda Kabaroğlu, Oya Bayındır
Objective: Cardiovascular diseases (CVD) are the leading causes of death worldwide. After understanding the importance of inflammation in the pathogenesis, CRP usage has been increased for the determination of cardiovascular risk. As an inflammation marker, the relationship...
Journal of Turkish Clinical Biochemistry
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2007-08-01
Celal Kurt, Sembol Yıldırmak, Murat Usta, Ömer Emecen
Aim: The aim of this study is to investigate the possible effects of chronic smoking on serum vitamin D
and some inflammation markers.
Materials and Methods: The smoking history of a total of 110 volunteer adults, 76 females and 34
males, for whom 25...
Journal of Turkish Clinical Biochemistry
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2021-08-01
Derya Koçer, Fatma Mutlu Sarıgüzel, Emel Güler, Çiğdem Karakükcü, Serap Tomruk Sütbeyaz, Ahmet Gödekmerdan
Objective: Ankylosing spondilitis (AS) is a chronic inflammatory disease involving primarily the skeletal
system, the peripheral joints and extra-articular structures. C-reactive protein (CRP) and erythrocyte
sedimentation rate (ESR) are commonly used assays for measuring...
Journal of Turkish Clinical Biochemistry
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2014-08-01
A. Erkin Bozdemir, Burcu Barutçuoğlu, Fatih Ekren, Ceyda Kabaroğlu, Gürhan Günaydın, Sara Habif, Çağ Çal, Oya Bayındır
Objective: Prostate specific antigen (PSA) and ma ny other tumor markers are suggested to be useful for the biologic activity of the prostate cancer. The aim of our study is to investigate possible relationship between inflammatory markers (high sensitive C-Reactive Protein...
Journal of Turkish Clinical Biochemistry
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2006-12-01
Hüseyin Kurku, İbrahim Solak, Yavuz Turgut Gederet, Mehmet Ali Eryilmaz
Aim: Smoking is accepted as a risk factor for primary chronic diseases such as cardiovascular diseases
and respiratory system diseases and for cancer development. The aim of this study was to indicate the
increase in inflammation in smokers by using high-sensitivity...
Journal of Turkish Clinical Biochemistry
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2021-04-01
Yeşim Güvenç, Mustafa Serteser, Ece Onur, Fatma Taneli, Soner Cander, Tülay Köken
Purpose: End-stage renal disease; is a disease characterized by loss of renal function where
inflammation is involved in its pathogenesis. Adiponectin is an anti-inflammatory protein secreted from
the adipose tissue. ICAM-1 and VCAM-1 are vascular adhesion molecules that...
Journal of Turkish Clinical Biochemistry
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2018-08-01
Sibel Bilgili, Gizem Yalçın, Giray Bozkaya, Nuriye Uzuncan, Arife Erdoğan
Purpose: Nitric oxide(NO) is one of the important substances that are synthesized to keep the blood
vessels dilated enough to provide adequate flow and to maintain cerebrovascular homeostasis. Creactive
protein(CRP) is a highly sensitive indicator of inflammation and tissue...
Journal of Turkish Clinical Biochemistry
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2020-12-01
Tufan Ermiş, Nevbahar Turgan, Biltan Ersöz
Trombomodulin (TM) is a 557 amino acid a glycosylated transmembrane protein and is a thrombin receptor located on endothelial cell surface. It was named as thrombomodulin due to its modulator role on the functions of thrombin. While a part of TMÕs physiological functions are through the activity...
Journal of Turkish Clinical Biochemistry
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2006-04-01
Işıl Çakır, Nahide Ekici Günay, Ahmet Oğuz Baktır
Objective: ST-segment elevation myocardial infarction (STEMI) is an important cause of morbidity and
mortality. Platelet (PLT) activation and thrombosis have important roles in the process of atherosclerosis
that is one of the most important cause of acute ischaemic...
Journal of Turkish Clinical Biochemistry
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2019-12-01
Beste Kipçak Yüzbaşı, Esin Avcı Çiçek, Olcay Güngör, Hülya Aybek, Hande Şenol
Aim: Valproic acid is a commonly used therapeutic agent in childhood epilepsies. Monitoring toxic doses of valproic acid is important due to serious adverse effects such as hepatotoxicity and encephalopathy. In this study, we aimed to investigate the relationship between...
Journal of Turkish Clinical Biochemistry
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2025-12-01
Emin Savaş Kılavuz, Nermin Erol
Objective: The aim of this study is to examine the effect of hypeglycemic peak induced by OGTT on
the basal inflammatory state by exploring the serum CRP level diffferencesMaterial and
Methods: I24 patients for suspicous of diabetes who have applied...
Journal of Turkish Clinical Biochemistry
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2009-08-01
Tugba Arıkan, Mehmet Kelles, Selman Sarıca, Metin Kılınc
Objective: It has been demonstrated that oxidative stress induced tissue damage plays a role in the
pathogenesis of several otolaryngological diseases. The aim of the present study was to evaluate the
selenium (Se), zinc (Zn) and copper (Cu) levels in the plasma of children...
Journal of Turkish Clinical Biochemistry
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2018-12-01
Merve Zeytinli Akşit, Yasemin Delen Akçay, Çiğdem Gözde Aslan, Yusuf Ali Altuncı, Murat Ersel, Alper Bozdoğan
Aim: We aimed to reveal the potential roles of periostin, hypoxia-inducible factor-1α (HIF-1α), and phospholipase A2 (PLA2) in inflammation, hypoxia, and tissue damage in patients with coronavirus disease 2019 (COVID-19) and to investigate whether they are useful potential...
Journal of Turkish Clinical Biochemistry
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2025-12-01
Burcu Barutçuoğlu, A. Erkin Bozdemir, Güneş Başol, Zuhal Parıldar, Ceyda Kabaroğlu, M. Işıl Mutaf, Oya Bayındır
Objective: The increase in serum procalcitonin (PCT) levels is a marker of severe systemic inflammation due to bacterial infection and renal excretion plays an important role in its elimination. The aim of this retrospective study is to investigate the relationship between...
Journal of Turkish Clinical Biochemistry
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2008-04-01
Gökhan Utku, Sembol Türkmen Yıldırmak, Müberra Vardar, Ekrem Özakın, Yüksel Gülen Özbanazı, Veli Mihmanlı, Hatice Birgül Ayabakan, Hülya Çerçi
Objective: Pre-eclampsia is a pregnancy specific form of hypertension and a multisystem disorder of maternal and placental origin. Pregnancy associated plasma protein-A (PAPP-A) is a insulin like growth factor binding protein 4- degrading metalloproteinase. The aim of this...
Journal of Turkish Clinical Biochemistry
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2013-08-01
Can Duman, Emin Alioğlu
Objective: It is well known that chronic inflammation is an important factor of the process which leads to atherosclerosis. While leading to atherosclerosis inflammation can cause acute phase response as well. CRP, serologic indicator of inflamation, synthesized in liver, is...
Journal of Turkish Clinical Biochemistry
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2006-08-01
Özben Özden Işıklar
Galectin-3 is a multifunctional protein that plays a critical role in inflammation, apoptosis, and fibrosis. It is considered a biomarker and therapeutic target in cardiovascular and neurodegenerative diseases, as well as pulmonary, hepatic, and renal fibrosis. Additionally, it is associated with...
Journal of Turkish Clinical Biochemistry
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2025-04-01
Tuba Hancı, Hakan Türkön, Ayfer Çolak Aydoğdu, Ömür Yıldız, İsmail Karademirci, Işıl Çoker
Objective: Obesity is the leading public health problem in this century. In this study we aimed to evaluate the hsCRP levels which are the indicators of inflammation in obese people (defined with BMI) and assess the relation between obesity and hsCRP.
Materials...
Journal of Turkish Clinical Biochemistry
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2012-04-01
Kadir Kaba, Fadime Pınar Ateş, Süleyman Berk Akbaş, Ali Muhtar Tiftik
Aim: Immature granulocytes, an indicator of increased myeloid cell production, are associated with infection or systemic inflammation. Data on the use of immature granulocyte levels as a biochemical marker in infection and inflammatory conditions have been reported. In our...
Journal of Turkish Clinical Biochemistry
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2024-08-01