Objective: Adiponectin, is a novel adipose tissue specific protein that has structural homology collagen VIII, X and complement factor C1q. It is also shown that insulin resistance and obesity cause to diminish adiponectin extraction from human adipose tissue but the...

Objective: Obesity promotes the development of diseases in many organ systems. The relationship between lipoporotein (a), lipid parameters and insulin resistance which accompany obesity has not been clarified. The correction of dyslipidemia in obesity and insulin resistance is...

Objective: In this study, we aimed to evaulate serum C-reactive protein (CRP), interleukin 6 (IL-6), and neopterin levels with lipoprotein phospholipase A2(Lp-PLA2) activity in obese adolescents with or without insulin resistance, and to demonstrate their relationships with...

Objective: The aim of the present study is to investigate the relation between new obesity indices waist circumference/height (WtHR), visceral adiposity index (VAI) and body adiposity index (BAI) and homeostasis model assessment of insülin resistance (HOMA-IR) index and...

Objective: Plasminogen activator inhibitor type I (PAI-1) an inhibitor of fibrinolysis and an important and independent cardiovascular risk factor, has been shown to be elevated in obesity. The aim of this study was to evaluate plasma PAI-1 levels in obese subjects and to...

Diabetes mellitus is a metabolic disease characterized by hyperglycemia resulting from defective insulin secretion or resistance to insulin action, or both. Production of sugar alcoholes called as metabolic hypothesis, ischemia-hipoxia oxidative stress, and insufficiency of neurotrophin or...

Objective: The aim of this study is to determine the correlation between insulin resistance and serum IL-8 levels of obese individuals with normal glucose tolerance.

Materials and Methods: 72 obese individuals with the ages ranging from 20 to 59 and...

Objectives: Despite various studies on the effect of thyroid status on insulin sensitivity in recent years, there are conflicting data. Thyroid dysfunction leads to changes in glucose and lipid metabolism, which is an important risk factor for cardiovascular diseases. For this...

Aim: Pancreatic cancer (PC) is a disease with complex and poorly understood etiology. One of the common risk factors of PC is diabetes mellitus (DM). Increased carbohydrate antigen (CA) 19-9 levels can be used as a biomarker in diagnosis of PC. However, CA 19-9 levels have...

Objective: The discovery of vitamin D receptors and vitamin D activating enzymes in several cells other than those involved in bone and mineral metabolism brought the non-classical effects of vitamin D into focus. It was reported that diabetic patients have significantly...

Aim: The aim of this study was (1) to compare the serum insulin, ghrelin, obestatin and, copeptin levels between pregnant and non-pregnant women and (2) investigate the changes in these parameters in pregnant women that measured at before and second hour after 75 gram (g)...

Fatty acid-binding proteins (FABPs) are abundant 14-15-kDa cytoplasmic proteins expressed in almost all mammalian tissues. They coordinate lipid responses in cells and related with metabolic and inflammatory pathways. FABPs bind to hydrophobic ligands, such as saturated and unsaturated long-chain...

Aim: Polycystic ovarian syndrome (PCOS) is a multifactorial disorder with different phenotypic characteristics, the most frequent endocrine disorder in women, and the leading cause of anovulatory infertility. Kisspeptin is recognized to have a crucial function in regulating...

Objective: Metabolic syndrome is a comorbidity of insulin resistance, impaired glucose tolerance, abdominal obesity, hypertension and dyslipidemia and associated with increased risk of cardiovascular disease. The secretion of adipocytokines such as leptin and adiponectin...