Diabetes mellitus is a metabolic disease characterized by hyperglycemia resulting from defective insulin secretion or resistance to insulin action, or both. Production of sugar alcoholes called as metabolic hypothesis, ischemia-hipoxia oxidative stress, and insufficiency of neurotrophin or...

Alcohol addiction is one of the leading reasons of liver diseases in many countries. Hepatic steatosis, alcoholic hepatitis, hepatic fibrosis and cirrhosis can be mentioned among the diseases resulting due to alcohol addiction. In recent years, studies have been focused on effect oxidant stress...

Objective: The aim of the study was to investigate the relationship between viral load and lipid peroxidation and antioxidant enzymes in patients with hepatitis B virus (HBV) infection.

Materials and Methods: We examined 50 patients (26 male, 24 female)...

Objective: We aimed to determine the relationship between some oxidative and antioxidant parameters and cancer status. Therefore, the activity of serum PON1, an enzyme known as a lipid antioxidant, as well as serum level of TBARS, the end product of lipid peroxidation, and...

Hyperhomocysteinemia is a recently recognized independent risk factor for cardiovascular diseases. Although the mechanism of vascular damage in hyperhomocysteinemia has not been completely understood, it may lead to this condition by increasing free radical production and lipid peroxidation,...

Objective: Sperm cryopreservation is the procedure of freezing sperms without loosing their liveliness in various oncological and/or immunological diseases and fertilization problems arousing from the treatments of these diseases. However, a decrease in sperm motiliy, cell...

Objective: The aim of this study was to evaluate the effects of nicotine on myocardium of newborn rats whose mothers received nicotine during gestation and lactation, by using biochemical and pathological parameters and to evaluate the role of antioxidant enzymes, free oxygen...

Objective: Stroke, in all over the world, the one of the leading causes of morbidity and mortality especially in the geriatric population. Oxidative stress has an important role in pathophysiology of ischemic stroke. Malondialdehyde (MDA) is an important parameter of...

It has been reported that oxidative stress is increased in diabetes mellitus and the increase in oxidative stress gives rise to complications of this disease. In the present study, we aimed to investigate the effects of vitamin A, E, and C treatments combined with insulin on the oxidative and...

Aim: During iron deficiency anemia (IDA), increased oxidative stress is accompanied by reduction in antioxidant defense systems and increased lipid peroxidation. We aimed to assess oxidative balance and Deoxyribonucleic Acid (DNA) damage in reproductive-aged women with...

Objective: Nicotine is an important component of cigarette smoke. Nicotine administration may result in oxidative stress by inducing the generation of reactive oxygen species in the periphery and central nervous system. Numerous epidemiological studies have demonstrated an...

Objective: In this study, we aimed to evaluate the possible effects of leptin and oxidative stress on the pathogenesis of type 1 and type 2 diabetes mellitus.

Material and Methods: Subjects were assigned to four groups: type 1 diabetes group (n=20),...

Objective: Defibrotide, a polydeoxyribonucleotide, has been found to modulate endothelial cell function and to have an antithrombotic effect on arteries, veins and capillaries. A significant amonut of evidence has been found about the protective role of defibrotide in...

Purpose: Obstructive jaundice leads to hepatic injury and fibrosis. Icterus causes immunologic depression resulting in bacterial translocation. In this study, we aimed to investigate the effects of vitamin E and L-arginine supplementation on glutathione systems and bacterial...

Purpose: To investigate the effects of melatonin on serum paraoxonase and lactonase activities in isoproterenol-induced myocardial infarction.

Materials and Methods: Rats were divided into four groups as control, melatonin, ISO and ISO+melatonin....

Objective: Breast cancer is one of the most frequent types of cancers seen in women, especially in industrial societies. It is a heterogeneous and complex disease affected by genetic, diet and environmental factors. This study intends to investigate if there is a significant...

Endometriosis is frequently associated with infertility and spontaneous abortus. Studies which had been carried on the subjects with endometriosis revealed the abnormal expression of the antioxidant defense enzymes, and suggested an inbalance in free radical metabolism. This study was designed to...