Aim: The aim of this study was to extensively evaluate four fully-automated photometric methods directly measuring antioxidant capacity; ferric ion reducing power, total antioxidant status, total antioxidant response, total thiol and to reveal the weak and strong sides of...

Objective: Graves' disease is an autoimmune disease which results in excessive production of thyroid hormones and is the most common cause of hyperthyroidism. TRAb has a key role to confirm the clinical diagnosis of Graves' disease. The different measurement methods have...

Aim: /b> In this study, we evaluated the analytical performance and diagnostic adequacy of the activity and mass methods used for the measurement of CK-MB, a laboratory marker for the diagnosis of acute myocardial infarction (AMI). In addition, the differences between CK-MB...

µ-FADU (Fluorometric Analysis of DNA Unwinding) and COMET are methods developed for the rapid detection of DNA damage and repair capacity. Both are based on time dependent alkaline DNA unwinding under appropriate denaturing conditions. COMET and µ-FADU are fluorometric and spectroflurometric...

Objective: This study aimed to evaluate the agreement between albumin measurements obtained via capillary zone electrophoresis (CZE) and bromocresol green (BCG) methods and to determine their interchangeability in clinical practice. Additionally, it explored how these results...

Aim: Since glomerular filtration rate (GFR) determined by 24 hours urine is cumbersome, nephrologists recommend using an estimated GFR (eGFR). This study aimed to investigate the agreement between Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease...

Objective: Therapeutic drug monitoring for lithium therapy is important because of its narrow therapeutic range and non-specific nature of clinical findings of lithium toxicity. Methods such as ion-specific electrode (ISE), atomic absorption and flame emission have been used...

Background: Bromcresol green (BCG) and Bromcresol Purple (BCP) which are dye-binding based methods are widely used in serum albumin analysis in clinical laboratories for many years. It was suggested that discrepancies exist between these methods and these discrepancies are...

Objective: Intact parathyroid hormone is used for diagnostic follow up in chronic kidney disease mineral bone disorder. Studies have shown that there was considerable bias between methods intact parathyroid hormone assays. This study has investigated the variation between...

Objectives: The carbohydrate antigen 19-9 assay is a widely used biomarker as a complement to other tests in the detection and follow-up of pancreatic, bile duct and colon cancer in high-risk individuals. The CA 19-9 assays often give different results with different...

Objective: After proving that chronic low grade inflammation is an important component of atherosclerotic process, C-reactive protein (CRP) has been started to be used for atherosclerotic vascular disease risk determination together with the other risk factors. In practice, to...

Objective: In quantitative analysis of serum proteins turbidimetric and nephelometric methods are the most common. Aim of this study was to compare the nephelometric method with the turbidimetric method for serum and urine samples in our clinical laboratory and to analyse...

Objective: Method comparison experiments are based on comparison of samples results analyzed by the new test method and previously accepted method. In this study is aimed to compare reversedphase cation exchange chromatography with boronate affinity chromatography method...

The abuse of addictive drugs has been increasing world-wide and causing serious social problems. The development and application of analytical methods of the abused drugs in biological specimens are very important for the prediction of and protection from the risk to human health. Drugs of abuse...

Purpose: The measurement of serum ferritin is used as a reliable and noninvasive method for the monitoring of iron stores. There are many different methods for the ferritin measurement. However, the immunoturbidimetric method that having the less cost and possibility of the...

Objective: It's important to determine reliable reference intervals for all the test parameters of the clinical laboratory, but it's usually hard to obtain useful and necessary clinical data. Although the procedure of indirect determination of reference intervals using...

The use of C-reactive protein (CRP) analyses in different fields of clinical practice is increasing each day. In particular, investigations indicating the potency of C-reactive protein as a marker in predicting future coronary heart disease and cerebrovascular disease in healthy people are...

Objective: Measurement of HbA1c is widely used in patients with diabetes mellitus as a monitor of retrospective glycemic control. Currently, more than 30 different methods are commercially available to measure HbA1c and these methods vary in the fraction of Hb measured and the...

Screening for fecal occult blood has been shown to be effective in reducing the colorectal cancer mortality. Guaiac-based tests are one of the most frequently used screening tests, but their false positivity and negativity rates are quite high. Peroxidase enzyme, found in many fruits and...

Aim: Point Of Care (POC) tests are quick tests that shorten the treatment period and are portable devices, which are easy to use for non-laboratory personnel. In this study we aimed to compare the results of INR (International Normalized Ratio) that were studied with POC...

Aim: Method evaluation studies should be carried out for every new method planned to be used in laboratories. The aim of this study is to determine the analytical performance of the immunoassay method used for determining of plasma 25-hydroxy vitamin D levels and also to...

Objective: Reduced glutathione is the most important antioxidant molecule of intracellular medium and a good marker for investigating antioxidant defence mechanism in diseases which are caused by oxidative stress. In this study we compared the spectrophotometric measurement...

Objective: For the appropriate treatment of patients with chest-pain, measuring true CK-MB values is important for the early identification of myocardial infarction. The objective of our study was to compare the diagnostic value of the two different methods in patients with...

Aim: Beta thalassemias are common autosomal recessive inherited hemoglobinopathy worldwide. Hemoglobin A2 levels are the most important parameter used to determine beta-thalassemia carriers. One of the most commonly used methods for HbA2 measurement is high-performance...

Aim: Preanalytical errors, particularly during venous blood collection, are a significant source of laboratory diagnostic inaccuracies, accounting for most laboratory mistakes. Addressing these errors through systematic monitoring and targeted interventions is critical for...