Belgin Şenol, Ceyda Kabaroğlu, Saliha Aksun, Sara Habif, Işıl Mutaf, Nevbahar Turgan, Dilek Özmen, Hakan Kültürsay
Purpose: In the recent years, the relationship between inflammation and atherosclerosis induced, which is a chronic inflammatory disease, acute coronary syndromes, including unstable angina and acute myocard infarction, has gained importance. Acute phase reactants, as...
Journal of Turkish Clinical Biochemistry
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2003-12-01
Duygu Kumbul Doğuç, Medine Cüre, Yusuf Kara, Recep Sütçü, Namık Delibaş
Objective: Nicotine is an important component of cigarette smoke. Nicotine administration may result in oxidative stress by inducing the generation of reactive oxygen species in the periphery and central nervous system. Numerous epidemiological studies have demonstrated an...
Journal of Turkish Clinical Biochemistry
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2008-12-01
Yeşim Güvenç, Ece Onur, Ahmet Var, Hasan Aydede, Bekir Sami Uyanık
Objective: Portal hypertension is a hyperdinamic circulation disorder characterized by high portal venous pressure. The aim of the study is to reveal oxidative damage measuring nitric oxide levels and myeloperoxidase, xanthine oxidase, superoxide dismutase and glutathione...
Journal of Turkish Clinical Biochemistry
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2006-12-01
Sibel Bilgili, Gizem Yalçın, Giray Bozkaya, Nuriye Uzuncan, Arife Erdoğan
Purpose: Nitric oxide(NO) is one of the important substances that are synthesized to keep the blood
vessels dilated enough to provide adequate flow and to maintain cerebrovascular homeostasis. Creactive
protein(CRP) is a highly sensitive indicator of inflammation and tissue...
Journal of Turkish Clinical Biochemistry
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2020-12-01
Sabriye Kaya, Sevgi Eskiocak, Hüseyin Ahmet Tezel, Ali Rıza Soylu, Hasan Celalettin Ümit, Sedat Özdemir, Zeliha Türkyılmaz
Objective: Colorectal cancer is one of the most endemic cancers causing significant health problems which decreases life quality and causes job loss. As in several cancer types, it is assumed that oxidative damage and consequent inşammation may have an effect on colorectal...
Journal of Turkish Clinical Biochemistry
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2012-08-01
Handan Ak Çelik, Hikmet Hakan Aydın, Ceyda Kabaroğlu, Can Duman, Ece Onur Aydemir, Oya Bayındır
Objective: Defibrotide, a polydeoxyribonucleotide, has been found to modulate endothelial cell function and to have an antithrombotic effect on arteries, veins and capillaries. A significant amonut of evidence has been found about the protective role of defibrotide in...
Journal of Turkish Clinical Biochemistry
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2006-08-01
Berna Yalçın, Can Duman, Mustafa B. Çekmen, Berrin Çetinarslan, Zeynep Cantürk, Sarper Erdoğan, Hacı Kahya Özdoğan, İstemihan Tengiz, Ertuğrul Ercan
Aim: The oxidative stress which is caused by free radicals can play role in emerging and/or progressing many diseases. Hyperthyroidism can induce a lot of changes dealing with the systems of nitric oxide (NO) and antioxidant systems of several tissues in increasing the...
Journal of Turkish Clinical Biochemistry
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2004-04-01
Figen Narin, Selda Yavaşcan, Nazmi Narin, Hülya Akgün, Ali Baykan, Kazım Üzüm, Recep Saraymen
Objective: The aim of this study was to evaluate the effects of nicotine on myocardium of newborn rats whose mothers received nicotine during gestation and lactation, by using biochemical and pathological parameters and to evaluate the role of antioxidant enzymes, free oxygen...
Journal of Turkish Clinical Biochemistry
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2006-08-01
Hicran Hiçyılmaz, Nigar Yılmaz, Recep Sütçü, Hüseyin Vural, Namık Delibaş
Objective: The aim of this study was to evaluate serum total, HDL and LDL cholesterol and triglyceride levels and nitric oxide (NO) levels in rats with dietary walnut consumption.
Materials and Methods: The rats were divided into 2 groups as a control...
Journal of Turkish Clinical Biochemistry
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2007-12-01
Elvin Aliyev, Abdulkadir Yıldırım, Serap Yıldırım, Engin Şebin
Objective: The aim of this study is to investigate whether there is any protective effect of a regular
endurance exercise on the L-Thyroxine-induced oxidative stress in lung tissue of rats.
Materials and methods: Twenty-three male Sprague Dawley rats...
Journal of Turkish Clinical Biochemistry
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2014-04-01
Serpil Bayır, Sevgi Eskiocak, Şemsi Altaner, Erol Çakır
Dietary cholesterol is suggested to cause atherosclerosis and to increase the production of free radicals. It is reported that hypercholesterolemic diet may make some changes on the antioxidant system. In our study, we aimed to observe the effect of N-acetylcysteine (NAC) treatment on the...
Journal of Turkish Clinical Biochemistry
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2006-04-01
Özben Özden Işıklar, Işıl Mutaf
Asymmetric dimethylarginine (ADMA) is an amino acid that looks like arginine and exists in plasma,
urine and tissues. ADMA occurs naturally by methylation of arginine remnants in proteins and the
studies about it increases every day. ADMA, as a major inhibitor of nitric oxide sentase is...
Journal of Turkish Clinical Biochemistry
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2010-08-01
Kenan Güçlü, Fahri Bayram, Gülden Başkol, Osman Başpınar, Aydoğan Aydoğdu
Aim: To investigate the presence of oxidative stress and dyslipidemia, which increase cardiovascular
risk, and the effect of gonadotropin replacement therapy on these parameters in patients with
Idiopathic Hypogonadotropic Hypogonadism (IHH).
Material and...
Journal of Turkish Clinical Biochemistry
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2022-04-01
Nejla Barış, Nevbahar Turgan, Biltan Ersöz
Recent research, concentrating on the significance of L-arginine, a basic amino acid, with respect to medical biochemistry is noteworthy. The fact that L-arginin is a nitrogen donor in nitric oxide (NO) biosynthesis provokes interest toward this amino acid. In healthy adults arginine is not...
Journal of Turkish Clinical Biochemistry
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2004-08-01
Ahmet Var, Yeşim Güvenç, Ece Onur, Kemal Özbilgin, Gülşen Giray, Özer İlkgül, Zeki Arı
Purpose: Portal hypertension (PHT) is a common clinical syndrome, characterized by a pathological increase in portal pressure and hemodynamic changes. It is known that the oxidative stress is a mediator in the pathogenesis of PHT. Beta-blockers (propranolol), somatostatin and...
Journal of Turkish Clinical Biochemistry
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2003-12-01
V. Ercan Dinçel, Hamza Özer, Aylin Sepici-Dinçel, Sacit Turanlı
Synovial chondromatosis is a metaplastic pathology seen as multiple nodules localized in synovial joints, bursae and tendon sheath. Generally differential diagnosis can easily be done by typical radiological and histological properties. In this case report, the, nitrite-nitrate and superoxide...
Journal of Turkish Clinical Biochemistry
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2009-08-01
Said Sami Erdem, Fikret Kanat, Ali Ünlü
Objective: The aim of our study was to determine serum ADMA, NO and arginine levels in patients with COPD.
Material and Methods: Seventy five COPD subjects participated in this study. To be selected patients had to have no other diseases. The control...
Journal of Turkish Clinical Biochemistry
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2008-12-01