Objective: Plasminogen activator inhibitor type I (PAI-1) an inhibitor of fibrinolysis and an important and independent cardiovascular risk factor, has been shown to be elevated in obesity. The aim of this study was to evaluate plasma PAI-1 levels in obese subjects and to...

Objective: The aim of the present study is to investigate the relation between new obesity indices waist circumference/height (WtHR), visceral adiposity index (VAI) and body adiposity index (BAI) and homeostasis model assessment of insülin resistance (HOMA-IR) index and...

Aquaporins are small membrane proteins which their molecular weight is approximately 30 KDa. Aquaporins family has 13 members. Aquaporins transport the water through the membranes. Some of them also transport polar and small substances such as glycerol and urea. Aquaporin-7 is most abundant in...

Objective: Obesity promotes the development of diseases in many organ systems. The relationship between lipoporotein (a), lipid parameters and insulin resistance which accompany obesity has not been clarified. The correction of dyslipidemia in obesity and insulin resistance is...

Background: A sedentary lifestyle is associated with cardiometabolic risk factors and obesity. This study aims to investigate the effects of regular exercise training, acute exercise, and a sedentary lifestyle on levels of miRNA-33, miRNA-335, miRNA-370, miRNA-758, which...

Objective: Metabolic syndrome is a comorbidity of insulin resistance, impaired glucose tolerance, abdominal obesity, hypertension and dyslipidemia and associated with increased risk of cardiovascular disease. The secretion of adipocytokines such as leptin and adiponectin...

Objective: Adiponectin, is a novel adipose tissue specific protein that has structural homology collagen VIII, X and complement factor C1q. It is also shown that insulin resistance and obesity cause to diminish adiponectin extraction from human adipose tissue but the...

Objective: In this study, we aimed to evaulate serum C-reactive protein (CRP), interleukin 6 (IL-6), and neopterin levels with lipoprotein phospholipase A2(Lp-PLA2) activity in obese adolescents with or without insulin resistance, and to demonstrate their relationships with...

Aim: Leptin is a nonglycolyzed peptide, made of 146amino-acids, that is produced by ob-gene in fat tissue. Leptin in circulation shows its effects by inhibiting Neuropeptide-Y in central nervous system and shows its effects on body fat mass by decreasing appetite and...

Fatty acid-binding proteins (FABPs) are abundant 14-15-kDa cytoplasmic proteins expressed in almost all mammalian tissues. They coordinate lipid responses in cells and related with metabolic and inflammatory pathways. FABPs bind to hydrophobic ligands, such as saturated and unsaturated long-chain...

Objective: The discovery of vitamin D receptors and vitamin D activating enzymes in several cells other than those involved in bone and mineral metabolism brought the non-classical effects of vitamin D into focus. It was reported that diabetic patients have significantly...

Objective: In recent years hsCRP and procalcitonin has started to be used in diagnosis and assessment of the prognosis of cardiovascular diseases. In this study we aimed to evaluate the prognostic significance of alterations in C-reactive protein (CRP) and procalcitonin...

Objective: The aim of this study is to determine the correlation between insulin resistance and serum IL-8 levels of obese individuals with normal glucose tolerance.

Materials and Methods: 72 obese individuals with the ages ranging from 20 to 59 and...