Purpose: The correct analysis of types and amounts of amino acids is highly important in the diagnosis of inborn errors of metabolism. The results obtained from heel blood drop and plasma of patients who were referred from primary health care institutions with pre-diagnosis...

Purpose: The aim of the present study was to investigate the effects of taurine on plasma paraoxonase, arylesterase and lactonase activities in streptozotocin-induced experimental diabetes.

Materials and Methods: Thirty-six Sprague-Dawley female rats,...

Aim: Oxysterols are derivatives of cholesterol which are formed by oxidation through numerous chemical reactions and play an important role in many physiological processes and in various degenerative and metabolic diseases, lipid metabolism disorders. In this study, analytical...

Objective: It has been demonstrated that oxidative stress induced tissue damage plays a role in the pathogenesis of several otolaryngological diseases. The aim of the present study was to evaluate the selenium (Se), zinc (Zn) and copper (Cu) levels in the plasma of children...

Objective: Vitamin D has several functions in cell growth, immunity, and metabolism. Vitamin D deficiency has been associated with rickets. In deficient states, there is a higher risk for autoimmune diseases, cancers, myocardial infarction, diabetes, and infectious diseases....

Aim: /b> In this study, we evaluated the analytical performance and diagnostic adequacy of the activity and mass methods used for the measurement of CK-MB, a laboratory marker for the diagnosis of acute myocardial infarction (AMI). In addition, the differences between CK-MB...

Objective: Autoimmunity is an important factor in the pathogenesis of Behcet Disease emphasized in recent years In recent studies, Vitamin D has been demonstrated to play a significant role in immune system functioning. The measurement of plasma 25-hydroxyvitamin D3levels,...

In chronic renal failure, high plasma homocysteine levels are a common finding and in uremia almost the rule. The cause of hyperhomocysteinemia in ESRD (end stage renal disease) whether it lies in an impared renal or extrarenal metabolism or through uremic retention toxins, is still under...

Objective: It has been reported that glucose intake creates changes at the levels of some electrolytes in serum and urine. The most important change observed in urine is the increase in calcium levels and this is thought to be the result of increased insulin levels in response...

Objective: Colorectal cancer is one of the most endemic cancers causing significant health problems which decreases life quality and causes job loss. As in several cancer types, it is assumed that oxidative damage and consequent inşammation may have an effect on colorectal...

Objective: Recurrent lactate and blood gas analysis are frequently assessed in intensive care units of anesthesiology to evaluate the metabolism. Two separate blood samples, a sample with heparin as an anticoagulant for one for blood gas analysis and the second sample with...

High-sensitivity cardiac troponin T (hs-cTnT) assays are crucial in evaluating chest pain, but their increased sensitivity makes them susceptible to pre-analytical interferences. False-positive results may lead to unnecessary clinical interventions, especially in pediatric populationsa...

Background: A sedentary lifestyle is associated with cardiometabolic risk factors and obesity. This study aims to investigate the effects of regular exercise training, acute exercise, and a sedentary lifestyle on levels of miRNA-33, miRNA-335, miRNA-370, miRNA-758, which...

Objective: In clinical laboratories, the tests of prothrombin time (PT), and partial thromboplastin time (aPTT) are generally analysed fastly after blood collection. In addition to this, sometimes the blood samples can be kept as frozen in order to be analysed at a later...

Objective: Atherosclerotic cardiovascular disease is the leading cause of the increased morbidity and mortality observed in uremic patients. The prevalance of cardiovascular diseases is high in the dialysis patients. Thrombosis is an important contributor to the evolution of...

Aim: The aim was to determine if the malondialdehyde (MDA) and advanced oxidation products of protein (AOPPs) levels, which are oxidative stress parameters, can be used to determine the degree of coronary artery disease.

Materials and Methods: The...

Objective: The aim of our study was to determine serum ADMA, NO and arginine levels in patients with COPD.

Material and Methods: Seventy five COPD subjects participated in this study. To be selected patients had to have no other diseases. The control...

Aim: Method evaluation studies should be carried out for every new method planned to be used in laboratories. The aim of this study is to determine the analytical performance of the immunoassay method used for determining of plasma 25-hydroxy vitamin D levels and also to...

Objective: Pre-eclampsia is a pregnancy specific form of hypertension and a multisystem disorder of maternal and placental origin. Pregnancy associated plasma protein-A (PAPP-A) is a insulin like growth factor binding protein 4- degrading metalloproteinase. The aim of this...

Dietary cholesterol is suggested to cause atherosclerosis and to increase the production of free radicals. It is reported that hypercholesterolemic diet may make some changes on the antioxidant system. In our study, we aimed to observe the effect of N-acetylcysteine (NAC) treatment on the...

Hyperhomocysteinemia and increased ACE activity due to the deletion polymorphism of the ACE gene are two common features in a wide variety of pathological conditions that exhibit endothelial disturbances. In this study, we examined both the I/D genotype distribution and the activity of ACE in...

Objective: Plasminogen activator inhibitor type I (PAI-1) an inhibitor of fibrinolysis and an important and independent cardiovascular risk factor, has been shown to be elevated in obesity. The aim of this study was to evaluate plasma PAI-1 levels in obese subjects and to...

Objective: Mean platelet volume (MPV) is a determinant of platelet function. Determining the MPV levels is very important for the diabetic patients who have the risk of developing vascular diseases. The aim of this study is to investigate any significant difference in the...

Objective: The purpose of this study is to determine the median values of the double test screening parameters in Bursa region and to reevaluate the test results positive risky pregnancies according to previous computer programme.

Materials and Methods:...