Aim: Raynaud's phenomenon is characterized by transient reduction in blood supply through the small arteries in the hands and feet. Secondary Raynaud's phenomenon accompanies collagen vascular diseases such as rheumatoid arthritis and scleroderma. The relationship between...

Aim: The Intra-laboratory Turnaround Time (IR-TAT) serves as a significant measure of overall laboratory efficacy. This study sought to augment laboratory operational productivity and diminish IR-TAT by instating a Total Laboratory Automation (TLA) system, executing stat...

Aim: The evaluation of biomarkers linked with inhibition and activation of vascular calcification in pre and post renal transplant period in renal transplant recipients was aimed in this research.Patients and

Methods: 35 recipients who had undergone...

Objective: Prostate specific antigen (PSA) and ma ny other tumor markers are suggested to be useful for the biologic activity of the prostate cancer. The aim of our study is to investigate possible relationship between inflammatory markers (high sensitive C-Reactive Protein...

Objective: However, the analytical and standardization problems have continued, vitamin D status is usually assessed by measuring the plasma concentration of 25-hydroxyvitamin D [25(OH)D]. The aim of this study was to compared vitamin D levels of 50 healthy volunteers...

Objective: Oxidative stress is suggested to play key role in the pathogenesis of inflammatory bowel diseases. Protein oxidation resulting from oxidative damage is notified in ulcerative colitis which is the one of the inflammatory bowel diseases. The aim of the study was to...

Objective: It has been proposed that the homocysteine (Hcy) produced during the metabolism of methionine plays a role in etiopathogenesis of several diseases. The interest in measurement of plasma Hcy levels has increased recently upon the finding that Hcy is an independent...

Objective: The aim of this study was to evaluate the effects of nicotine on myocardium of newborn rats whose mothers received nicotine during gestation and lactation, by using biochemical and pathological parameters and to evaluate the role of antioxidant enzymes, free oxygen...

Objective: The use of glycemic markers in the follow-up of Diabetes Mellitus is important to prevent the development of complications. Glycated hemoglobin (HbA1c) is more stable and exhibits glucose status of 8-12 weeks, while fasting plasma glucose (APG) reflects the...

Purpose: Activation of the renin-angiotensin system leads to an increase in oxidative stress. We investigated erythrocyte antioxidant enzymes, glutathione peroxidase, glutathione reductase and glutathione-S-transferase activities and as an index for oxidative stress plasma...

Objective: The objective of this study was to evaluate of accuracy of the immuno-turbidimetric method.

Material and Methods: Patients (n=160) were tested with the D-Dimer assay with a STalia®D-DI (D-dimer) (Diagnostica Stago, Asnieres, France). D-dimer...

Objective: Smoking is one of the most important cause of cardiovascular disease and known as a preventable risk factor. Lipoproteins especially LDL has an important role in cardiovascular disease. Normally high density lipoproteins protect LDL from oxidation; proinflammatory...

Objective: Although people do not feel, but usually exposed to t he electromagnetic fields; itsbiological effects of have been commonly reported . The aim of the study was to investigate the effect of electromagnetic field on MDA which is considered to be a carcinogenic...

The direct link between cardiovascular disease and plasma cholesterol levels has been clearly described. Therapeutic interventions for lowering plasma cholesterol levels have a great significance in prevention of cardiovascular diseases. In enterocytes, numerous transport molecules in charge...

Hyperhomocysteinemia and increased ACE activity due to the deletion polymorphism of the ACE gene are two common features in a wide variety of pathological conditions that exhibit endothelial disturbances. In this study, we examined both the I/D genotype distribution and the activity of ACE in...

Objective: A natural anticoagulant Protein C and its cofactor free Protein S, play an important role in the development of thrombosis in diabetics. In this study, we compared Protein C and Protein S concentrations in type 2 diabetic patients and healthy controls and observed...

Objective: The prevalence of coronary artery disease is much higher in men than in women and sex hormones might play a role in these differences via their influence on lipid profile. However, the role of sex hormones in the relationship between male gender and cardiovascular...

There is no a standart pr ocedure to assess instrument quality on technical and analytical performance of glucometers yet. We made up our protocole considering NCCLS EP9-A2 (National Commitee for Clinical Laboratory Standarts EP9-A2) and ISO 15197 (International Organization for Standardization...

Aim: Physical, sexual, biological, psychological and social changes occur in the adolescent period. Vitamin D is an anti-inflammatory hormone that regulates the body's calcium (Ca) and phosphorus (P) balance, provides bone development, contributes to the formation of the...

Hepcidin, a recently discovered peptide hormone, is the homeostatic regulator of intestinal iron absorption, iron recycling by macrophages and iron mobilization from hepatic stores. Hepcidin inhibits the cellular efflux of iron by binding to and inducing the degradation of ferroportin. Hepcidin...

Asymmetric dimethylarginine (ADMA) is an amino acid that looks like arginine and exists in plasma, urine and tissues. ADMA occurs naturally by methylation of arginine remnants in proteins and the studies about it increases every day. ADMA, as a major inhibitor of nitric oxide sentase is...

Insufficiency in one or more male genital organs is the cause of infertility in more than %50 of the affected couples. For this reason; a close examination of the semen is an important factor in pinpointing the source and the cause of infertility. In addition; this examination avails the...

Aim: The uncertainty of measurement is an important indicator for both the expediency of a method and the reliability of analytical results obtained in a laboratory. Accreditation processes such as ISO 15189 also expect laboratories to have a defined method for measurement...

Objective: The aim of this study is to determine the new median values of biochemical analytes used in double and triple prenatal screening tests and to compare these values with the median values of the package program used in screening tests.

Materials and...