Objective: Anemia is a commonly encountered health problem. In this study, togetherness of beta thalassemia trait with iron deficiency anemia was investigated using by some biochemical and hematological cell count indices.

Material and Methods: The...

The importance of laboratory medicine during COVID-19 pandemic has once again become a current issue. With COVID-19 pandemic, very important changes have occurred in terms of laboratory processing. Some of these changes were measures related to employee health, planning regarding the...

Fatty acid-binding proteins (FABPs) are abundant 14-15-kDa cytoplasmic proteins expressed in almost all mammalian tissues. They coordinate lipid responses in cells and related with metabolic and inflammatory pathways. FABPs bind to hydrophobic ligands, such as saturated and unsaturated long-chain...

Scanning methods for mutation detection are important especially for research and diagnosis of inherited metabolic diseases and cancer. Many techniques were described for detection of unknown mutations. In the present review, current methods such as Ribonuclease cleavage, Denaturing Gradient Gel...

The use of C-reactive protein (CRP) analyses in different fields of clinical practice is increasing each day. In particular, investigations indicating the potency of C-reactive protein as a marker in predicting future coronary heart disease and cerebrovascular disease in healthy people are...

Sickle cell disease is a blood disorder that affects erythrocytes one of the most common single gene disorders in the world and the incidence is high in Turkey. Mutation in the beta globin gene leads to the formation of sickle hemoglobin tetramers. These tetramers polymerize and damage the...

The abuse of addictive drugs has been increasing world-wide and causing serious social problems. The development and application of analytical methods of the abused drugs in biological specimens are very important for the prediction of and protection from the risk to human health. Drugs of abuse...

Objective: Automated hematology analyzer flags may provide early warning signals for hematological malignancies. This study aimed to evaluate the diagnostic performance of Sysmex XN-1000 analyzer flags and to develop a multivariable prediction model for identifying active...

Amyotrophic lateral sclerosis (ALS) is a fatal disorder of motor neuron degeneration with unclear etiology and no effective treatment to date. The cause of the most cases of ALS remains unknown. Research in ALS has been stimulated by a series of genetic and molecular pathology discoveries. ALS...

Under the physiological conditions, protein excretion in urine is less than 150 mg per day. Proteinuria is defined as an excessive rate of protein excretion in the urine. Measurement of proteinuria and identification of its components are important for the diagnosis of various clinical settings....

Numerous preanalytical variables that affect the coagulation testing have been defined over the years. The three potential main topics where coagulation testing preanalytical issues may arise are specimen collection (including patient selection), specimen transportation and stability, specimen...

Asymmetric dimethylarginine (ADMA) is an amino acid that looks like arginine and exists in plasma, urine and tissues. ADMA occurs naturally by methylation of arginine remnants in proteins and the studies about it increases every day. ADMA, as a major inhibitor of nitric oxide sentase is...

Aim: We aimed to demonstrate the interference in Hemoglobin A1c (HbA1c) testing in a patient diagnosed with Evans syndrome, a rare condition characterized by autoimmune hemolytic anemia.

Case: A patient who presented to our laboratory for biochemical...

Adipose tissue which is currently considered as an endocrine organ produces several bioactive factors named as adipocytokines. Adipocytokines, apart from their local effects in adipose tissue may produce effects in distant organs through systemic circulation. Visfatin is a newly discovered...

Conjugated linoleic acid (CLA) refers to a class of positional and geometric conjugated isomers of the omega-6 essential fatty acid, linoleic acid (LA). In 1987 anticancerogen properties of CLA were first discovered by Pariza and coworkers coincidentally. Since these early discoveries, an array...

It is known that anti-platelet drugs reduce the vascular pathologies in patients with cardiovascular disease. Despite using these drugs there are still a number of patients suffering from vascular events. Even though monitoring antiplatelet drug therapy with platelet function tests is...

Transforming growth factor-β(TGFβ) has a crucial role in tissue homeostatsis and disruption of TGFβ signaling pathway has been implicated in cancer. As a potential inhibitor of epithelial cell proliferation and inflammatory response, together with a proapoptotic effect, TGFβ is a tumor...

Galectin-3 is a multifunctional protein that plays a critical role in inflammation, apoptosis, and fibrosis. It is considered a biomarker and therapeutic target in cardiovascular and neurodegenerative diseases, as well as pulmonary, hepatic, and renal fibrosis. Additionally, it is associated with...

Neutrophil gelatinase-associated lipocalin (NGAL), is a small, robust protein expressed by neutrophils and various epithelia, including the renal proximal tubules. While initially proposed as a marker for infections and certain adenocarcinomas, it is now apparent that its early and dramatic rise...

Some urinary enzymes and low molecular weight proteins have been used as early markers of kidney damage and useful for the detection of small changes in the function of tubular epithelial cells in many pathological conditions. Their excretions increase long before elevation of other markers of...

Children are quite different from adults not only as structurally, but also their metabolism and in terms of their response to the diseases. The most important variable is the age of the pediatric patients. Clinical biochemist must have knowledgeable about the differences in the interpretation...

Aquaporins are small membrane proteins which their molecular weight is approximately 30 KDa. Aquaporins family has 13 members. Aquaporins transport the water through the membranes. Some of them also transport polar and small substances such as glycerol and urea. Aquaporin-7 is most abundant in...

Hemophilia A and B are X-linked bleeding disorders characterized by the absence or reduced activity of coagulation caused by mutations in the factor VIII and factor IX genes, respectively. Diagnosis of hemophilia is based on understanding the clinical features and symptoms of hemophilia,...

Laboratory data are very important in the diagnosis of diseases. The correct interpretation of laboratory data would help clinician to rule in or rule out the diagnosis. For the appropriate interpretation of laboratory tests, the diagnostic accuracy of the tests should be known. One of the...

In research studies performed to enlighten the diagnosis and pathogenesis of various diseases and to investigate possible treatment strategies, experimental animal models provide many advantages to the investigators. Diabetes Mellitus is a chronic metabolic disease which lasts for whole life,...